Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 231-240 of 525 results
Inflammation Research, 2024 • February 11, 2024
This study used Mendelian randomization to investigate the causal effects of lipid-lowering drug targets on psoriatic arthritis (PsA) risk. The analysis revealed a significant association between gene...
KEY FINDING: Genetically proxied PCSK9 inhibition is associated with a decreased risk of psoriatic arthritis (OR: 0.51; 95% CI 0.14–0.88; P < 0.01).
eNeuro, 2024 • February 1, 2024
The study investigated the effect of chronic SSRI treatment on serotonin axon regrowth in mice after a chemical lesion induced by para-chloroamphetamine (PCA). Mice were treated with fluoxetine or ser...
KEY FINDING: Chronic treatment with either fluoxetine or sertraline, two different SSRIs, did not affect the recovery of serotonin axon length in the somatosensory cortex, visual cortex, or hippocampus.
Nanomaterials, 2024 • February 20, 2024
This study successfully synthesized a curcumin-decorated nanozyme (PMC NPs) with significant ROS scavenging and anti-inflammatory properties for neuroprotection. In vitro experiments demonstrated that...
KEY FINDING: PMC NPs exhibit specific SOD-like and CAT-like activities, enabling them to effectively scavenge ROS in physiological conditions.
ACS Pharmacol. Transl. Sci., 2024 • February 7, 2024
This study investigates the role of LIM kinases (LIMKs) in spinal cord injury (SCI) and associated neurodegeneration, focusing on their impact on microtubule dynamics and neuronal regeneration. The fi...
KEY FINDING: Phosphorylated LIMK1 is elevated at chronic time points after SCI, correlating with scar formation and neuronal loss.
Cells, 2024 • March 24, 2024
The advance of nanotechnologies for the treatment of refractory spinal cord pathologies requires an in-depth understanding of neurobiological and topographical principles and a consideration of additi...
KEY FINDING: Nanoparticle size, shape, and surface chemistry are critical factors influencing their interaction with biological systems, affecting drug delivery and cellular uptake in SCI treatment.
Regenerative Biomaterials, 2024 • April 10, 2024
This study investigates a multifunctional DSCM hydrogel incorporating curcumin and NT-3 for spinal cord injury (SCI) therapy, demonstrating enhanced NSCs proliferation and neuronal differentiation. Th...
KEY FINDING: The integration of both NT-3 and curcumin significantly enhanced NSCs proliferation and their neuronal differentiation.
Bioeng Transl Med, 2024 • January 1, 2024
This study introduces a novel approach for spinal cord injury (SCI) repair using plant-derived exosomes (PEs) extracted from Lycium barbarum L., loaded with isoliquiritigenin (ISL) and integrated into...
KEY FINDING: PEs from L. barbarum L. possess anti-inflammatory and neuronal differentiation promotion capabilities, showing enhanced neural differentiation compared to exosomes from ectomesenchymal stem cells (EMSCs).
Cureus, 2024 • June 21, 2024
Organophosphates (OP) are widely used pesticides that can cause delayed neurotoxicity, a rare condition where neurological symptoms manifest weeks after initial exposure. This case report presents a 2...
KEY FINDING: A 28-year-old male developed delayed myelopathy five weeks after acute chlorpyrifos poisoning, presenting with lower limb weakness, abnormal gait, and sensory loss.
Neural Regeneration Research, 2025 • June 1, 2025
This review examines the benefits of using nanoparticles for SCI treatment and investigates the pathophysiology and therapeutic approaches of SCI. The review highlights various nanoparticles' roles in...
KEY FINDING: Nanoparticles can effectively cross the blood-spinal cord barrier (BSCB), allowing drugs to reach the injury site more efficiently than traditional methods.
Frontiers in Pharmacology, 2024 • August 6, 2024
This editorial provides an overview of the current research landscape regarding advanced neural stem cell therapies for spinal cord injury (SCI). It summarizes key articles published on the topic, hig...
KEY FINDING: Stem cell therapy, particularly using Mesenchymal Stem Cells (MSCs) and Neural Stem Cells (NSCs), shows promise for treating SCI, although firm evidence of a cure is lacking.