Pharmacology Research

KEY FINDING: Polysaccharide-based DDSs, especially those using chitosan, alginate, and agarose, show promise in treating SCI by promoting axonal regeneration and reducing inflammation.

KEY FINDING: The AttFPGNN-MAML method outperformed other methods on three out of four tasks in the MoleculeNet dataset, demonstrating superior performance in few-shot learning settings.

KEY FINDING: Rats receiving the combination therapy displayed an increased response to quipazine, achieving a BBB score of ≥9 starting at 8 weeks post-injury, which persisted through 12 weeks.

KEY FINDING: Wheelchair users experienced bone loss compared to those who could walk.

KEY FINDING: The review papers assembled match the temporo-spatial progression of SCI, from acute considerations at the site of injury, to subacute processes at and beyond the injury, to chronic changes away from the site of injury.

KEY FINDING: Substantial differences exist among SCI centers in the indications for UTI treatment, medications used, and treatment duration, often deviating from existing guidelines.

KEY FINDING: Two podhfr mutations, S58R and S113N/T, were detected in P. ovale curtisi with high/moderate frequencies.

KEY FINDING: NASCIS-II methylprednisolone did not improve motor score recovery in RHSCIR patients with acute TSCIs in either the cervical or thoracic spine when the influence of anatomical level and severity of injury were included in the analysis.

KEY FINDING: Inhibition of the Rho-ROCK pathway reverses the effects of myelin-associated inhibitors, promoting axonal regeneration and functional recovery in the injured CNS in vivo.

KEY FINDING: EPO treatment resulted in a more rapid recovery in SCI rats, as evidenced by higher BBB scores.