Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 481-490 of 525 results
Eur Spine J, 2004 • August 14, 2003
This technical note presents a minimally invasive technique using topical rt-PA for evacuating extensive spinal subdural haematomas in two patients on long-term anticoagulation therapy. The technique ...
KEY FINDING: Topical application of rt-PA allows evacuation of the haematoma through a limited surgical exposure.
BioMed Research International, 2017 • June 12, 2017
This review explores using curcumin to treat spinal cord injuries (SCI) by regulating the mTOR signaling pathway, potentially offering new therapeutic avenues. mTOR signaling is crucial in axon regene...
KEY FINDING: The mTOR signaling pathway plays a vital role in the functional recovery of the central nervous system trauma, especially for axon regeneration and autophagy.
J Neurotrauma, 2021 • February 1, 2021
This study investigates the effects of low-dose, site-directed estrogen delivery via nanoparticles on spinal cord injury (SCI) in rats. The researchers hypothesized that this method would reduce infla...
KEY FINDING: Site-directed estrogen delivery reduced lesion size, reactive gliosis, and glial scar formation compared to controls.
Journal of Pain Research, 2016 • August 31, 2016
This study evaluated the relationship between plasma concentrations of cannabinoids and the analgesic response to vaporized cannabis in 42 subjects with central neuropathic pain. The study found dose-...
KEY FINDING: Dose-dependent improvement in pain score was evident across all pain scale elements after administration of vaporized cannabis.
Cell Death Discovery, 2024 • April 24, 2024
This study investigates the therapeutic potential of salidroside in treating spinal cord injury (SCI). The research focuses on salidroside's impact on nerve regeneration, glial scar formation, astrocy...
KEY FINDING: Salidroside enhances functional recovery in SCI mice by promoting axonal regeneration, myelin reconstitution, and inhibiting glial scar formation and the activation of neurotoxic A1 astrocytes.
CNS Neuroscience & Therapeutics, 2024 • January 1, 2024
CNS tumors are complex diseases with specific pathogeneses not fully understood and poor prognosis, often resistant to therapies. ncRNAs, including circRNAs, significantly contribute to tumor initiati...
KEY FINDING: CircRNAs participate in multiple molecular mechanisms of cellular normal or pathophysiology processes, especially as miRNA sponges in the cytoplasm, activating the modulation of target genes via miRNA response elements.
Chembiochem, 2020 • April 1, 2020
This study demonstrates the ability of OleD Loki to glycosylate a diverse set of HDAC inhibitors, forming hydroxamate glycosyl esters. The resulting glycosylated products exhibited reduced cytotoxicit...
KEY FINDING: OleD Loki can convert a wide range of HDAC inhibitors into their corresponding hydroxamate glycosyl esters.
Journal of Nanobiotechnology, 2022 • December 28, 2022
The study developed CaO2@mPDA-SH nanoparticles that can regulate the tumor microenvironment by consuming lactic acid and alleviating hypoxia. The nanoparticles promote immune responses, inhibit angio...
KEY FINDING: CaO2@mPDA-SH nanoparticles can dually regulate tumor hypoxia and lactic acid metabolism.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study evaluated the impact of long-term nitrofurantoin for UTI prophylaxis in veterans with SCI. Long-term prescription of nitrofurantoin may reduce UTIs in veterans with SCI and there is no evid...
KEY FINDING: UTIs were less frequent in cases receiving long-term nitrofurantoin compared to controls.
The Journal of Neuroscience, 2017 • August 30, 2017
This study investigates the role of 2-arachidonoylglycerol (2-AG), the major CNS endocannabinoid, in the modulation of chondroitin sulfate proteoglycans (CSPGs) deposition in a progressive model of mu...
KEY FINDING: Inhibition of 2-AG hydrolysis reduces CSPGs accumulation and astrogliosis around demyelinated lesions in the spinal cord of Theiler’s murine encephalomyelitis virus-infected mice.