Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 61-70 of 525 results
Advanced Science, 2022 • March 4, 2022
This systematic review supports the idea that medical gases can protect cells against common diseases by controlling oxidation, inflammation, and cell death. Carbon monoxide can help restore nerve func...
KEY FINDING: Medical gases like carbon monoxide (CO) and xenon (Xe) show promise in protecting tissues and improving function, particularly in the central nervous system (CNS), heart, retina, liver, kidneys, and lungs.
Annals of Medicine and Surgery, 2022 • March 1, 2022
This case report presents an instance of bullous pemphigoid developing after the second dose of the Pfizer COVID-19 vaccine in an elderly man. The patient presented with bullae and intense pruritus af...
KEY FINDING: A 78-year-old man developed bullous pemphigoid after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine.
Pharmaceuticals, 2022 • April 11, 2022
This review focuses on the potential of Serotonin 1A receptor agonists to improve locomotor and respiratory functions in individuals with spinal cord injury (SCI). The study highlights the efficacy of...
KEY FINDING: 5-HT1A receptor agonists have shown positive changes in locomotor function in animal models of SCI or in humans.
Pharmacol Res Perspect, 2022 • April 9, 2022
The study investigates the paralytic effects of a novel botulinum toxin A (A/Chin) on rat gastrocnemius muscle, comparing its efficacy and duration to other BTX-A formulations with and without complex...
KEY FINDING: A/Chin demonstrates a rapid and consistent time-to-peak paralytic effect, reaching its peak on day 3 post-injection.
Frontiers in Microbiology, 2022 • May 10, 2022
This study developed phage cocktails effective against E. coli strains isolated from urine of patients with spinal cord injury (SCI), which exhibit strong biofilm-forming properties, addressing the cha...
KEY FINDING: Nine phages were identified that individually decreased cell viability by >80% when added to biofilms of two E. coli strains in human urine.
Spinal Cord Series and Cases, 2022 • April 7, 2022
This case report highlights an instance of transient alterations in consciousness in a 43-year-old male with spinal cord injury following baclofen initiation, which resolved upon baclofen discontinuat...
KEY FINDING: Baclofen can cause transient alterations of consciousness in SCI patients, mimicking orthostatic hypotension.
Journal of Nanobiotechnology, 2022 • June 4, 2022
The study introduces a novel biomimetic synthesis method for ultrasmall Pd nanoclusters (Pd@insulin) using insulin as a template, demonstrating its effectiveness in scavenging ROS and improving outcom...
KEY FINDING: Insulin-incubated palladium clusters (Pd@insulin) were successfully synthesized using a green biomimetic method and exhibited excellent multiple ROS-scavenging ability.
NeuroReport, 2022 • January 1, 2022
This study investigates the neuroprotective effect of Notoginsenoside R1 (NGR1) in rats with spinal cord injury (SCI) and its underlying mechanism. Results demonstrate that NGR1 administration reduces...
KEY FINDING: NGR1 administration enhances neurological function and mitigates tissue damage and motor neuron loss after SCI compared to the vehicle group.
Frontiers in Endocrinology, 2022 • June 20, 2022
This study investigates the interaction between melanocortin 1 receptor (Mc1r) and melanocortin receptor-associated proteins (Mraps) in Xenopus tropicalis. The research combines in silico analysis wit...
KEY FINDING: xtMc1r interacts directly with xtMrap1 and xtMrap2 proteins on the plasma membrane, validated through co-immunoprecipitation and fluorescence.
Frontiers in Pharmacology, 2022 • July 8, 2022
This study investigates the neuroprotective effects of catalpol (CAT) on spinal cord injury (SCI) in rats. The research demonstrates that CAT promotes functional recovery in SCI rats by inhibiting ER ...
KEY FINDING: CAT has a restorative effect on the lower limb motor function of rats with SCI.