Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 51-60 of 525 results
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This study aimed to identify polypharmacy rates, risk factors, and commonly prescribed medications among individuals with SCI to inform medication management practices. The study found that 45% of ind...
KEY FINDING: The most commonly treated conditions among SCI patients were pain (56.5%), muscle spasms (54%), and urinary tract infections (43%).
Nutrients, 2021 • June 11, 2021
This systematic review assessed the literature on dietary supplements for sport performance in para-athletes, identifying 15 relevant studies. The review found that evidence supporting supplement use ...
KEY FINDING: Evidence for the effectiveness of supplements like caffeine, creatine, and vitamin D in para-athletes is inconclusive, with results varying across studies.
Curr Opin Pharmacol, 2021 • October 1, 2021
Severe SCI leads to rapid muscle atrophy due to neural insult, paralysis, systemic inflammation, hormonal imbalances, and glucocorticoid treatment. The review discusses the SCI muscle phenotype, molec...
KEY FINDING: Muscle loss after SCI is more rapid than in other disuse conditions, with distinct molecular signaling cascades.
Brazilian Journal of Medical and Biological Research, 2021 • November 1, 2021
This retrospective study compared the efficacy and safety of tolperisone versus baclofen in Chinese patients with spasticity due to spinal cord injury. Patients received baclofen plus physical therapy...
KEY FINDING: Both baclofen plus physical therapy and tolperisone plus physical therapy significantly improved muscle tone and strength compared to physical therapy alone.
Frontiers in Pain Research, 2022 • July 28, 2022
This review explores the emerging evidence for intrathecal management of neuropathic pain following spinal cord injury (SCI). It highlights the challenges in treating neuropathic pain in SCI patients ...
KEY FINDING: Neuropathic pain after SCI involves complex mechanisms including neuronal excitability, glial dysregulation, and chronic inflammation.
Journal of Neurotrauma, 2021 • December 15, 2021
This study demonstrates that low-dose ampakine treatment can effectively increase diaphragm EMG activity after cervical SCI in rats, suggesting a potential pharmacological strategy for respiratory reh...
KEY FINDING: Both CX717 and CX1739 increased diaphragm EMG output ipsilateral to C2Hx during both baseline breathing and acute respiratory challenge at 4 days post-injury.
DRUG DELIVERY, 2021 • November 15, 2021
The study successfully designed and synthesized two novel optimized drug delivery microspheres, Lap/MS@Mel and PM/MS@Mel, for treating spinal cord injury in rats. The Lap/MS@Mel system facilitates pro...
KEY FINDING: Lap/MS@Mel hydrogels continuously released melatonin for at least 28 days in vitro, showing a more stable sustained release and better neural recovery ability in SCI rats.
Fluids and Barriers of the CNS, 2022 • January 4, 2022
This study introduces a novel method for non-invasive and selective opening of the BCSFB using a single low-energy focused shockwave pulse (FSW) with microbubbles to enhance drug delivery into CSF cir...
KEY FINDING: A single low-energy shockwave pulse can noninvasively and selectively open the BCSFB.
Cell J, 2021 • December 1, 2021
This study investigated the neuroprotective effects of methylprednisolone (MP) and fluoxetine (FLX) in a rat model of spinal cord injury (SCI) with induced hypothyroidism. The researchers examined the...
KEY FINDING: The combined treatment with MP and FLX significantly decreased the expression levels of TNF-α and IL-6 in rats with SCI and hypothyroidism.
Pharmaceuticals, 2022 • January 19, 2022
This study investigates the potential of cannabigerol (CBG) to trigger neuroregeneration after spinal cord injury using an in vitro model of NSC-34 scratch-injured cells, analyzing the transcriptome t...
KEY FINDING: CBG pre-treatment mitigates apoptosis signaling and manages oxidative stress in injured cells.