Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 221-230 of 292 results
Frontiers in Physiology, 2019 • February 8, 2019
This review discusses the biophysical, biochemical, and epigenetic processes involved in regenerative healing in amphibians, particularly tail and limb regeneration in Xenopus. The review highlights t...
KEY FINDING: Reactive oxygen species (ROS) signaling is rapidly activated after injury and is required for tail regeneration. Inhibition of ROS prevents full tail regeneration and affects the activation of Wnt signaling pathways.
Cerebral Cortex, 2020 • March 1, 2020
The study examines the functional maturation and integration of neuronal precursors in the adult murine piriform cortex, focusing on whether these precursors become equivalent to neighboring principal...
KEY FINDING: Young complex cells receive less synaptic input and fire action potentials at lower frequencies compared to mature principal neurons, similar to neonatal principal neurons.
Frontiers in Physiology, 2019 • November 13, 2019
This study investigated the neuroprotective effects of curcumin in a neonatal mouse model of hypoxic-ischemic (HI) brain injury. The researchers explored different administration times and dosages of ...
KEY FINDING: Curcumin administration prior to HIE in neonatal mice elevated cell and tissue loss, as well as glial activation compared to HI alone.
International Journal of Molecular Sciences, 2020 • October 13, 2020
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. The review aims to promote the understanding of SCI pathophys...
KEY FINDING: SCI pathophysiology includes acute and chronic phases with destructive events like ischemia, oxidative stress, inflammation, and apoptosis. Many therapeutic strategies have been proposed.
Brain Sci., 2021 • February 27, 2021
This systematic review synthesizes findings from studies using TMS–EEG co-registration in patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and other dementias. We aimed to revi...
KEY FINDING: TMS-EEG studies have identified a reduced TMS-evoked P30 response in AD patients, particularly in the temporo-parietal and fronto-central areas, indicating sensorimotor system rearrangement. The authors found in the AD patients a significantly decreased TMS-evoked P30 (time-locked response 30 ms after the TMS) in the temporo-parietal cortex ipsilateral to stimulation side and in the contralateral fronto-central area corresponding to the sensori-motor network
J Neurol Neurosurg Psychiatry, 2001 • October 1, 2001
This case documents convincingly, for the first time, a severe generalised sensory-motor polyneuropathy after electrical injury and records a remarkable degree of clinical and electrophysiological reco...
KEY FINDING: The patient developed a severe generalized sensory-motor polyneuropathy after high voltage electrical injury, leading to flaccid tetraplegia.
Exp Neurol, 2007 • August 1, 2007
The study investigates the physiological properties of regenerated sensory axons in the dorsal columns after spinal cord injury (SCI) in rats. It was found that regenerated axons, six months post-inju...
KEY FINDING: Regenerated axons had reduced conduction velocity compared to intact axons.
Exp Neurol, 2008 • January 1, 2008
The study addresses the challenge of culturing functional adult mammalian spinal-cord neurons for understanding and treating neurological disorders, particularly spinal cord injury. It demonstrates th...
KEY FINDING: Temporal incubation with serotonin, glutamate, and acetylcholine-chloride leads to full electrophysiological functional recovery of adult mammalian spinal-cord neurons in culture.
J Physiol, 2008 • March 27, 2008
The study investigates the impact of olfactory ensheathing glia (OEG) transplantation on the phenotypic characteristics of fast- and slow-twitch hind limb skeletal muscle in rats with completely trans...
KEY FINDING: OEG transplantation results in hind limb skeletal muscle phenotypes that are generally intermediate between paralyzed and control and different from both.
Exp Neurol, 2009 • September 1, 2009
This study investigates the conversion of crossed phrenic activity from a spontaneously active to latent status during postnatal development in rats. Crossed phrenic activity was spontaneously express...
KEY FINDING: Crossed phrenic activity is spontaneously expressed in all three parts of the ipsilateral hemidiaphragm of P2 rats following C2 hemisection injury.