Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 281-290 of 292 results
Eur Spine J, 2011 • December 5, 2010
This study investigated the effect of cervical radiculopathy on the cutaneous silent period (CSP), an electrophysiological measure of spinal inhibitory reflexes. The results showed that the CSP is pre...
KEY FINDING: The cutaneous silent period (CSP) was preserved in most patients with cervical radiculopathy, regardless of which finger was stimulated.
Brain and Behavior, 2021 • January 1, 2021
This review explores the neural basis of the Rubber Hand Illusion (RHI) using neurophysiological techniques like TMS, EP, ERP, and EEG, highlighting their crucial role in understanding RHI. Studies us...
KEY FINDING: TMS studies indicate that motor cortex excitability decreases when the real hand is disembodied during the RHI, and ownership of the rubber hand correlates with normal parietal-motor communication.
Skeletal Muscle, 2024 • May 13, 2024
The study investigates the impact of mouse strain, sex, and injury type on intramuscular fat (IMAT) formation, myofiber regeneration, and fibrosis. Results show that C57BL/6J mice are resistant to IMA...
KEY FINDING: Bl6 mice are more resistant to IMAT formation compared to 129S and CD1 strains.
Theranostics, 2024 • September 3, 2024
This study highlights a novel metabolic pathway involving MCT1-mediated lactate shuttling from endothelial cells to neurons, which is crucial for energy metabolism and axon regeneration after spinal c...
KEY FINDING: MCT1 expression is markedly decreased in endothelial cells (ECs) post-SCI, disrupting lactate transport to neurons.
Int J Dev Biol, 2015 • January 1, 2015
This study investigates the role of transmembrane voltage potentials (Vmem) in regulating apoptosis and proliferation during embryonic CNS development using Xenopus laevis embryos. Disrupting local Vm...
KEY FINDING: Disrupting local bioelectric signals in the developing neural tube increases apoptosis and decreases proliferation, leading to brain mispatterning.
Frontiers in Cellular Neuroscience, 2019 • July 24, 2019
This study investigates the pro-neuroregenerative activity of ENDF1, a prenylated flavonoid, on dorsal root ganglion (DRG) neurons in the presence of extracellular matrix (ECM) growth inhibitors. The ...
KEY FINDING: ENDF1 promotes neurite regrowth of DRG neurons despite the presence of inhibitory ECM molecules.
Respir Physiol Neurobiol, 2019 • July 1, 2019
This review discusses how local circulatory control and oxygen delivery in the spinal cord regulate different pathways to phrenic motor plasticity. Acute intermittent hypoxia (AIH) elicits distinct me...
KEY FINDING: Moderate AIH induces serotonin-dependent pLTF, which is independent of tissue hypoxia and relies on carotid body chemoreceptor activation.
J Neurophysiol, 2006 • April 1, 2006
This study examined the effects of long-term neuromuscular electrical stimulation (NMES) training on musculoskeletal health in individuals with acute spinal cord injury (SCI). The primary outcomes wer...
KEY FINDING: Long-term NMES training resulted in significant improvements in plantar flexor muscle properties, including increased peak torque (+24%), torque-time integral (+27%), fatigue index (+50%), and torque rise time (+45%).
J Biomech, 2017 • April 11, 2017
This study aimed to quantify anthropometric parameters in individuals with SCI and examine the effects of injury duration and obesity. The results indicate that mass distribution and tissue compositio...
KEY FINDING: Chronic SCI is associated with a shift in mass proportion from lower limbs to the trunk and upper arms, and decreased lean mass proportion, especially in the trunk.
Spinal Cord, 2018 • June 1, 2018
This study characterized hindlimb EMG patterns in rats with SCI in response to muscle stretch, identifying clonic-like, air-stepping, and spasm responses, which are similar to those seen in humans. Th...
KEY FINDING: Three main EMG patterns in response to stretch were identified: clonic-like, air-stepping, and spasms.