Physiology Research

KEY FINDING: SNI induces chronic pain and depressive-like behaviors in mice, evidenced by decreased mechanical pain threshold, thermal pain latency, and reduced exploratory behavior.

KEY FINDING: Only a couple of horses showed significant increases in mean muscle fiber size when Pre- vs Post-FES biopsies were compared, as expected for the FES treatment used.

KEY FINDING: Patients with SCI exhibited exaggerated auditory startle responses (ASRs) compared to healthy controls.

KEY FINDING: Hydrogen sulfide (H2S) has anti-inflammatory and anti-apoptotic effects and can protect the spinal cord. It reduces oxidative stress and promotes axon growth.

KEY FINDING: In both CaV1.3 and CaV1.2 channels, a mutation neutralizing the D4 charge (D4N) in voltage-sensing domain IV (VSD IV) resulted in a right-shift of the voltage-dependence of activation by approximately 5 mV.

KEY FINDING: DXA measurements were strongly correlated with MRI measurements for whole thigh muscle mass, absolute muscle mass (excluding intramuscular fat), and knee extensor muscle mass.

KEY FINDING: Sevoflurane upregulates the expression of ATPIF1 to induce inflammation and caspase-3 activation.

KEY FINDING: Thermoregulatory dysfunction in persons with SCI is proportional to the level of injury, with those with tetraplegia at greatest risk for heat-related illness.

KEY FINDING: Neither Acomys nor Mus recovered lost muscle mass or myofiber number within three months following VML injury, and Acomys also failed to recover force production better than Mus.

KEY FINDING: Spinal cord contusion associated with hypovolemia had a negative influence on functional outcomes of the spinal cord injury.