Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.
Showing 31-40 of 292 results
Neuromodulation, 2022 • December 1, 2022
This study used computational models and experimental testing to investigate HF-SCS recruitment of axons in the VLF and motoneurons innervating the inspiratory intercostal muscles. The study evaluated...
KEY FINDING: Model results suggested that within physiological stimulation amplitudes, HF-SCS activates both axons in the ventrolateral funiculi (VLF) and inspiratory intercostal motoneurons.
Experimental Brain Research, 2021 • July 2, 2021
This research explores spinal cord reflex responses to repetitive epidural stimulation in individuals with motor-complete SCI, focusing on monosynaptic and polysynaptic activity. The study identifies ...
KEY FINDING: Short-latency responses were enhanced at low frequencies but declined at higher stimulation rates.
Scientific Reports, 2021 • July 28, 2021
The study introduces a new wireless ventral spinal stimulation (VSS) system for rats, designed to target motor circuits in the cervical spinal cord while minimizing tissue damage. The VSS system enabl...
KEY FINDING: A wireless, fully implantable ventral spinal stimulation (VSS) system was developed and successfully implanted in rats.
Spinal Cord Series and Cases, 2021 • September 7, 2021
The study investigated changes in body composition in individuals with recent SCI during inpatient rehabilitation and up to one year post-discharge. Body composition remained relatively stable during ...
KEY FINDING: During inpatient rehabilitation, no significant changes in all body composition parameters were found.
Scientific Reports, 2021 • September 20, 2021
The study investigated the role of ankle muscle co-contraction on postural stability in individuals with incomplete spinal cord injury (iSCI) compared to able-bodied (AB) individuals. The iSCI group d...
KEY FINDING: Individuals with iSCI exhibited more co-contractions compared to able-bodied individuals during quiet standing with eyes open and closed.
Cureus, 2021 • October 16, 2021
This study aimed to determine the pathoanatomy of CSM in patients and analyze the correlations between clinical key symptoms, myelopathic signs, and MRI findings. The MRI parameters such as canal and ...
KEY FINDING: The most common myelopathic signs observed were positive Hoffmann’s sign and the presence of reverse brachioradialis reflex.
STAR Protocols, 2021 • December 17, 2021
This protocol details a method for using cortical EEG combined with in vivo multichannel recording to examine the activity of locus coeruleus (LC) neurons in free-moving mice at different sleep-wake s...
KEY FINDING: The study found that 52.1% of the channels can be successfully recorded to the LC unit.
Biosensors, 2021 • December 8, 2021
This study presents a novel system for simultaneous, multisite neural recording in freely moving rats, targeting the motor cortex, spinal cord, peripheral nerves, and muscles. The system's effectivene...
KEY FINDING: The developed system allows for simultaneous recording of neural and muscular activity from multiple sites in the motor pathway of freely moving rats.
Journal of Cachexia, Sarcopenia and Muscle, 2022 • January 9, 2022
This study demonstrates that Numb protein levels decline with age in skeletal muscle. The loss of Numb in skeletal muscle fibers leads to reduced contractile function, altered sarcomere length, and de...
KEY FINDING: Numb protein expression decreases significantly with age in mouse skeletal muscle.
Molecular Pain, 2022 • January 1, 2022
The study evaluated the effect of differential target multiplexed programming (DTMP) spinal cord stimulation (SCS) on proteins involved in ion transport regulation in the spinal cord of rats with neur...
KEY FINDING: DTMP modulated a larger number of proteins involved in ion transport regulation compared to LR SCS.