Browse the latest research summaries in the field of regenerative medicine & stem cells for spinal cord injury patients and caregivers.
Showing 11-20 of 2,317 results
Neural Regen Res, 2023 • January 30, 2023
The study investigated the role of serum response factor (SRF) in axon regeneration following spinal cord transection injury in rats. The researchers found that SRF expression increased after SCI and ...
KEY FINDING: SRF expression in injured spinal cord gray matter neurons gradually increased, peaking on the 7th day after injury.
Neural Regeneration Research, 2023 • January 5, 2023
The study investigates the role of gecko HSF1 (gHSF1) in regulating neurite outgrowth and inflammatory inhibition of macrophages following spinal cord injury using a gecko model. Results showed that g...
KEY FINDING: gHSF1 expression in neurons and microglia at the lesion site increased dramatically immediately after tail amputation.
Neural Regen Res, 2023 • March 3, 2023
Spinal cord injury (SCI) results in the interruption of axonal connections, leading to motor, sensory, and autonomic dysfunction. Mitochondrial dysfunction during the secondary stage of SCI exacerbate...
KEY FINDING: Mitochondrial dysfunction is intimately linked with axonal regeneration failure in the context of spinal cord injury.
Biomedicines, 2023 • May 8, 2023
This study investigated the effects of human adipose-derived stem cells (ADSC) on spinal cord injury (SCI) in rats. ADSC were infused into rats with SCI, and the researchers assessed cellular changes ...
KEY FINDING: The stem cells were observed migrating towards the injury site in the spinal cord.
Front. Neurol., 2023 • May 23, 2023
This study investigated the effects of plasma-synthesized polypyrrole/iodine (PPy/I) alone and in combination with swimming and enriched environment (SW/EE) rehabilitation on gene expression and locom...
KEY FINDING: PPy/I treatment upregulated genes related to developmental processes, biogenesis, synapses, and synaptic vesicle trafficking, suggesting a role in nerve regeneration and synaptic plasticity.
Cells, 2023 • May 25, 2023
This study aimed to evaluate the effectiveness of adipose-derived mesenchymal stromal cells (AD-MSCs) in treating severe spinal cord injury (SCI), focusing on functional recovery, angiogenesis, and ne...
KEY FINDING: AD-MSC transplantation combined with treadmill exercise training significantly improved motor function in severe SCI compared to other groups.
Clinical and Translational Medicine, 2023 • May 21, 2023
This study investigates the therapeutic effects of intravenous delivery of small extracellular vesicles (sEVs) derived from human mesenchymal stem/stromal cells (MSC) on body growth and motor recovery...
KEY FINDING: Intravenous delivery of human and rat MSC-sEVs improved functional motor recovery after SCI and restored normal body growth in young adult SCI rats.
World Journal of Stem Cells, 2023 • May 26, 2023
This review highlights the therapeutic potential of BMMSCs in treating SCI by summarizing their applications based on mechanisms like neuroprotection, axon regeneration, myelin repair, immunomodulatio...
KEY FINDING: BMMSCs exhibit neuroprotective effects by releasing growth and neurotrophic factors like BDNF, VEGF, and GDNF, enhancing regeneration and repair in damaged tissues.
Nature Communications, 2023 • July 12, 2023
This study introduces an advanced MN-MSC patch that enables sustained delivery of MSC-EVs to the injured spinal cord, avoiding direct stem cell invasion. The MN patch, made of biocompatible porous Gel...
KEY FINDING: The porous MN-MSC patch can effectively maintain the survival of MSCs and sustainably release MSC secretome for at least one week.
Frontiers in Immunology, 2023 • June 14, 2023
This study investigates the therapeutic mechanisms of transcranial intermittent theta-burst stimulation (iTBS) on nerve regeneration and functional recovery in rats with complete spinal cord transecti...
KEY FINDING: Transcranial iTBS reduces inflammation and neuronal apoptosis in the sensorimotor cortex (SMC) following spinal cord injury.