Regenerative Medicine & Stem Cells Research

KEY FINDING: Spinal interneuron reorganizations are subtype specific and may be adaptive or maladaptive for a given functional output.

KEY FINDING: Myelin-associated inhibitors like Nogo-A, MAG, and OMgp block neurite outgrowth by binding to receptors like NgR1, Pir-B, and others, initiating downstream signaling pathways like RhoA/ROCK, which leads to actin depolymerization and regeneration failure.

KEY FINDING: PLG bridge implantation modulates the cellular immune response in vivo by prolonging the macrophage/microglial response.

KEY FINDING: Identified 693 and 885 DEGs in old and young mice, respectively, after peripheral nerve injury, with shared DEGs involved in inflammatory and immune responses.

KEY FINDING: Cell transplantation therapy is more effective in the subacute phase of SCI than in the chronic phase.

KEY FINDING: HUES6 and iPSC neurospheres displayed markers associated with glial differentiation.

KEY FINDING: Following transplantation, the oNPCs engrafted, migrated to the rostral and caudal regions of the lesion, and demonstrated preferential differentiation toward oligodendrocytes.

KEY FINDING: TSIIA alleviates cell injury induced by LPS and increases TCTN2 expression in LPS-exposed NSC-34 cells.

KEY FINDING: The combination of hpMSCs-Exos and HBO significantly increased neuronal survival and decreased gliosis (proliferation of glial cells) in the spinal cord.

KEY FINDING: The combination of IL-6 and HU-210 stimulates neurite outgrowth in an inhibitory environment by promoting neuroprotection and enabling neurite outgrowth.