Regenerative Medicine & Stem Cells Research

KEY FINDING: NSC from E14 mice on multichannel PLG scaffold increases density of axons and myelin regeneration and leads to a more rapid and functional recovery

KEY FINDING: Single-cell RNA sequencing has identified latent lineage potential in neural stem cells (NSCs) in the spinal cord's ependymal region to differentiate into oligodendrocytes by regulating OLIG2 expression.

KEY FINDING: Satellite cells from spinal cord-injured individuals retain the capacity to differentiate into myotubes.

KEY FINDING: HGF-induced changes in gene expression were indicative of nerve regeneration and anti-inflammatory effects, in agreement with our earlier and simpler analysis of these RNA-seq data that then mostly neglected the time course of expression

KEY FINDING: A genome-scale CRISPR screen in hPSCs identified lineage-specification preventing genes (LPGs) that, when knocked out, cause the cells to differentiate into specific germ layers.

KEY FINDING: Tail amputation increases Sox2 mRNA and protein levels in the spinal cord, lateral line, and olfactory epithelium, indicating a systemic response to tissue injury.

KEY FINDING: Myelin debris clearance, axon regeneration, and function recovery were all faster in CD47−/− mice than in wild type mice.

KEY FINDING: MSCs from older patients show reduced proliferative capacity, skewed differentiation potentials, telomere shortening, and DNA damage accumulation.

KEY FINDING: VCAM1 is expressed on the cell surface of qNSCs in the adult hippocampus.

KEY FINDING: FM19G11 inhibits HIF1α and HIF2α protein accumulation in human tumor cell lines and stem cells from rodents and humans.