Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,511-7,520 of 7,812 results
Neural Regen Res, 2020 • June 19, 2020
This study compares the effectiveness of human umbilical cord-derived mesenchymal stem cells (UCMSCs) and human adipose tissue-derived mesenchymal stem cells (ADMSCs) in treating spinal cord injury (S...
KEY FINDING: Transplanted UCMSCs and ADMSCs similarly improved motor and sensory function after spinal cord injury in rats.
Scientific Reports, 2020 • July 9, 2020
This study investigates the structural adaptation of the ascending medial lemniscal pathway following a cervical dorsal column lesion in mice to reveal the rewiring strategies of sensory circuits. The...
KEY FINDING: Unilateral dorsal column lesions in mice are followed by recovery of tactile and proprioceptive function.
EPIGENETICS, 2021 • January 2, 2021
The study examines the distinct roles of 5hmC and 5mC in spinal cord injury and regeneration, specifically in the context of a folate-induced transgenerational phenotype. It identifies more than 2,800...
KEY FINDING: Differentially hydroxymethylated regions (DhMRs) and differentially methylated regions (DMRs) are largely unique, with distinct functions in axonal regeneration.
Scientific Reports, 2020 • July 15, 2020
This study demonstrates that Schwann cells transduced with lentiviral vectors encoding ChABC can constitutively secrete high quantities of active mChABC, leading to CS-GAG removal and altered cell beh...
KEY FINDING: mChABC robustly secreted from transduced Schwann cells leads to large-scale CSPG digestion, facilitating migration and adhesion on inhibitory substrates.
ACS Omega, 2020 • June 25, 2020
This study investigated the anti-inflammatory effects of bFGF and DPSCs, delivered via a thermosensitive hydrogel, in a rat model of spinal cord injury. The results showed that the combined use of bFG...
KEY FINDING: bFGF and DPSCs together effectively attenuate tissue inflammation in the injured spinal cord, leading to better nerve repair.
PLoS ONE, 2020 • July 17, 2020
The study introduces SUN13837, a novel small-molecule compound that mimics the beneficial effects of bFGF without its proliferative side effects. In vitro experiments demonstrated that SUN13837 promot...
KEY FINDING: SUN13837 promotes neurite outgrowth in primary cultures of rat hippocampal neurons, similar to bFGF.
STEM CELLS Transl Med, 2020 • September 1, 2020
This review summarizes the most promising preclinical and clinical cell approaches to date including transplantation of mesenchymal stem cells, neural stem cells, oligodendrocyte progenitor cells, Sch...
KEY FINDING: Cell-based therapies, including mesenchymal stem cells (MSCs), neural stem cells (NSCs), oligodendrocyte progenitor cells (OPCs), Schwann cells (SCs), and olfactory ensheathing cells (OECs), show promise in promoting neuroprotection and neuroregeneration after SCI.
J Comp Neurol, 2021 • January 1, 2021
This study used RNA sequencing to examine gene expression profiles in regenerating and nonregenerating spinal cords of opossums after injury at different ages. The study demonstrated a more complex an...
KEY FINDING: The study identified 558 genes whose expression changed after spinal cord injury, with most being upregulated.
Frontiers in Cellular Neuroscience, 2020 • July 2, 2020
This study explored mechanisms to modify Schwann cells (SCs) and astrocytes (ASs) characteristics and adjust the SC-AS interface to improve spinal cord injury (SCI) treatment benefits. Overexpression ...
KEY FINDING: Overexpressing miR-124 in SCs (miR-124-SCs) significantly inhibited gene and protein expression levels of SC-specific markers, such as GFAP and Krox20.
International Journal of Molecular Sciences, 2020 • August 1, 2020
This study demonstrates that noradrenergic innervation plays a significant role in locomotor recovery in paraplegic rats after intraspinal grafting of embryonic brainstem tissue, complementing the wel...
KEY FINDING: Morphological analysis revealed the presence of tyrosine hydroxylase positive (NA) neurons in addition to 5-HT neurons in the host spinal cords of grafted rats.