Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,521-7,530 of 7,812 results
BMC Musculoskeletal Disorders, 2020 • August 3, 2020
This study demonstrates that the neutrophil-to-lymphocyte ratio (NLR) at hospital admission is an independent predictor of 6-month outcomes in patients with acute cervical traumatic spinal cord injury...
KEY FINDING: Elevated NLR at admission is an independent predictor of poorer 6-month outcomes in patients with acute cervical tSCI.
Frontiers in Cellular Neuroscience, 2020 • July 2, 2020
Reactive glial scars and CSPGs inhibit axon regeneration after CNS injury, contributing to functional loss. CSPGs bind to receptors like PTPσ and LAR, activating intracellular signaling pathways that ...
KEY FINDING: PTPσ and LAR, two members of the LAR subfamily of receptor protein tyrosine phosphatases, bind CSPGs with high affinity and mediate suppression of axon elongation by CSPGs.
Frontiers in Cellular Neuroscience, 2020 • July 3, 2020
Functional recovery after CNS injury is limited by the failure of severed axons to regenerate and form functional connections. There has been little progress in restoring function to human patients wi...
KEY FINDING: Axon resealing after injury is an active, calcium-driven process, which facilitates cytoskeletal depolymerization and repolymerization needed to form a growth cone.
Biomedicines, 2020 • July 31, 2020
This study explores the potential of combined fasudil and menthol treatment to enhance recovery from spinal cord injury (SCI) in rats. The results indicate that the combined treatment significantly im...
KEY FINDING: Combined treatment with fasudil and menthol significantly improved locomotor function in rats with SCI, as indicated by higher BBB scores compared to single treatments or the injury-alone group.
Toxins, 2020 • July 31, 2020
The study investigates the therapeutic potential of Botulinum neurotoxin type A (BoNT/A) in treating spinal cord injury (SCI) in mice. BoNT/A is known for its ability to block SNARE complex formation ...
KEY FINDING: BoNT/A induces a complete recovery of muscle and motor function in a murine model of severe spinal cord injury (SCI) when administered spinally within one hour from spinal trauma.
Stem Cells International, 2012 • August 28, 2012
The review highlights the limitations of current SCI treatments and the need for innovative approaches to facilitate neural regeneration and functional improvement. Combination therapies, incorporatin...
KEY FINDING: Combination therapies, involving neurotrophins and cell grafts, cotransplantation of different grafts, or anti-inhibitory therapies, show enhanced efficacy compared to individual treatments.
Stem Cells International, 2020 • June 17, 2020
This study aimed to identify a cost-effective combination of growth factors to improve NPC survival and differentiation in vitro and in vivo after spinal cord injury (SCI). A combination of EGF, bFGF,...
KEY FINDING: A growth factor cocktail (EGF, bFGF, and PDGF-AA) increased NPC proliferation and directed cell fate towards the oligodendroglial and neuronal lineage while reducing astrocytic differentiation in vitro.
Journal of Biological Engineering, 2020 • July 27, 2020
Fibrin hydrogels are promising natural polymers for neural tissue engineering, offering biocompatibility and modifiability for carrying cells and therapeutic factors. Challenges remain in the clinical...
KEY FINDING: Fibrin hydrogels offer excellent biocompatibility, flexibility, and plasticity, making them suitable for neural tissue engineering and SCI repair.
Neural Regen Res, 2021 • January 1, 2021
Cathepsins are proteases vital for lysosomal function and involved in neuronal plasticity. Their activity must be tightly regulated to prevent detrimental effects. Following spinal cord injury, cathep...
KEY FINDING: Dysregulation of cathepsins, particularly after spinal cord injury, exacerbates inflammation and damages tissue, disrupting processes like autophagy and lysosomal function.
PNAS, 2010 • June 22, 2010
This study investigated the effect of sialidase on recovery from spinal cord contusion injury in rats. Sialidase was delivered intrathecally to the injury site for two weeks, and motor behavior, auton...
KEY FINDING: Sialidase treatment significantly enhanced hindlimb motor function in rats with spinal cord contusion injuries, as measured by the BBB locomotor rating scale.