Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,621-7,630 of 7,662 results
Bioeng Transl Med, 2024 • May 1, 2024
This study investigates the efficacy of photobiomodulation (PBM) in promoting neuroregeneration and functional recovery after spinal cord injury (SCI) using both implantable (iPBM) and transcutaneous ...
KEY FINDING: Optimal neuroprotection in vitro was achieved with PBM between 4 and 22 mW/cm2, with 11 mW/cm2 for 1 min per day (0.66 J/cm2) increasing cell viability by 45% and neurite outgrowth by 25%.
Journal of Clinical Orthopaedics and Trauma, 2022 • January 4, 2022
The Wnt/mTOR signaling pathway is a ubiquitous signaling cascade involved in various physiological and pathological processes, including those related to spinal cord injury (SCI). It plays a crucial r...
KEY FINDING: Wnt signaling plays an important role in SCI, regulating neural stem cell proliferation and differentiation, axon regeneration, neuroinflammation, and pain.
The Journal of Spinal Cord Medicine, 2015 • January 1, 2015
This study explored the feasibility of developing health system quality indicators for traumatic and non-traumatic spinal cord injury (SCI) using administrative data in Ontario, Canada. The objectives...
KEY FINDING: The study identified 7,693 SCI cases, with 20% categorized as traumatic SCI (TSCI) and 80% as non-traumatic SCI (NTSCI).
Journal of Translational Medicine, 2025 • February 11, 2025
This study investigated the effects of fecal microbiota transplantation (FMT) on motor function recovery in a spinal cord injury (SCI) mouse model. The results demonstrated that FMT restored gut micro...
KEY FINDING: FMT significantly improved motor function recovery in SCI mice compared to those treated with antibiotics alone, as shown by BMS scoring, inclined plane test, and footprint analysis.
Health Expectations, 2017 • March 7, 2017
The study highlights the need to respect patients' capacities and limitations in their decision-making ability during rehabilitation after a spinal cord injury (SCI). Patients often feel restricted in...
KEY FINDING: Patients experienced a reduced ability to participate in decision making during the early phase after SCI due to physical, psychological, and environmental factors.
Stem Cell Research & Therapy, 2020 • April 23, 2020
This study investigates the role of hepatocyte growth factor (HGF) in mesenchymal stem cell (MSC)-induced recovery in spinal cord injured (SCI) rats. The researchers found that MSCs promote neurologic...
KEY FINDING: Conditioned medium from bone marrow-derived MSCs (BMSCs) promotes neural stem cell differentiation into neurons and neurite outgrowth by inhibiting the BMP/Smad signaling pathway.
Stem Cell Reports, 2020 • July 14, 2020
The study investigates cell transplantation for SCI in chronic settings, using skin-derived precursors differentiated into Schwann cells (SKP-SCs) in rats 8 weeks post-injury. SKP-SCs survived transpl...
KEY FINDING: SKP-SCs survived long-term at the site of chronic SCI, integrated into the host spinal cord, and mitigated astroglial scar formation.
The Journal of Spinal Cord Medicine, 2016 • May 1, 2016
This study examined the cross-sectional associations between systemic inflammation and oxidative stress with pulmonary function in individuals with chronic spinal cord injury (SCI). The objective was ...
KEY FINDING: Higher levels of systemic inflammation (CRP and IL-6) were associated with lower percent-predicted FEV1 and FVC measurements in individuals with chronic SCI. participants with higher levels of CRP and IL-6 had lower percent-predicted FEV1 and FVC measurements.
The Journal of Spinal Cord Medicine, 2019 • March 1, 2019
This study estimated the lifetime cost of spinal cord injury (SCI) in Ontario from the perspective of the public healthcare payer. It used administrative health data to track healthcare costs of indiv...
KEY FINDING: The net lifetime cost of SCI was $336,000 per person.
The Journal of Spinal Cord Medicine, 2012 • January 1, 2012
This study examines the impact of therapeutic recreation (TR) interventions on various outcomes for patients with traumatic spinal cord injury (SCI) during inpatient rehabilitation and one year post-i...
KEY FINDING: TR interventions, such as community outings and leisure activities, contribute to positive outcomes at discharge (FIM, discharge to home) and one year post-injury (FIM, work/school, living at home, societal participation).