Spinal Cord Injury Research

KEY FINDING: Experimental SCI leads to inward cerebrovascular remodeling, increased stiffness, and impaired reactivity of the largest cerebral artery.

KEY FINDING: Cortical reorganization after spinal cord injury is species-dependent, with varying degrees and patterns observed in humans, non-human primates, and rats.

KEY FINDING: Individuals with tetraplegia reported better effectiveness scores compared to those with paraplegia, suggesting they perceive the decision-making process as more aligned with their needs.

KEY FINDING: The ABC scale demonstrated high test-retest reliability among participants with iSCI, indicating that individuals with iSCI reported very similar scores on two administrations of the ABC scale.

KEY FINDING: Acute microvascular disruption was evident post-SCI, particularly at the injury epicentre, spreading three spinal segments rostrally and caudally.

KEY FINDING: Diet compliance significantly decreased from 92.6% at 3 months to 43.0% at the 1-year follow-up (p < 0.01).

KEY FINDING: Motor function assessment indicated a relative recovery over time after spinal cord injury.

KEY FINDING: Subjects were able to safely complete at least 83% of the training sessions, demonstrating the feasibility of the program.

KEY FINDING: Transplantation of hTERT gene-transfected Schwann cells improved motor function in SCI rats between 1 and 4 weeks after model establishment.

KEY FINDING: Sleep-disordered breathing is prevalent in individuals with spinal cord injuries, especially those with motor-complete tetraplegia.