Browse the latest research summaries in the field of spinal cord injury for spinal cord injury patients and caregivers.
Showing 7,651-7,660 of 7,662 results
J Spinal Cord Med, 2010 • June 1, 2010
This case report highlights a previously unreported complication of fecal management systems: autonomic dysreflexia (AD) in patients with high-level spinal cord injuries. A 26-year-old man with C5 tet...
KEY FINDING: A fecal management system (FMS) used to manage fecal incontinence triggered autonomic dysreflexia in a patient with tetraplegia.
J Spinal Cord Med, 2008 • January 1, 2008
This study presents five cases of finger autophagia in individuals with tetraplegia following spinal cord injury, exploring potential causes and treatments for this self-injurious behavior. The findin...
KEY FINDING: Pain in the targeted limb was reported in only 1 of 5 patients, suggesting that self-injurious behavior was not primarily driven by pain in the affected area.
The Journal of Spinal Cord Medicine, 2018 • May 1, 2018
This study aimed to determine factors associated with functional status six months following a traumatic cervical and thoracic spinal cord injury (SCI), with a particular interest in factors related t...
KEY FINDING: Motor-complete SCI (AIS-A,B) was the main predictive factor associated with decreased total SCIM score in both tetraplegia and paraplegia.
Cureus, 2022 • May 30, 2022
Spinal cord injuries (SCI) initiate a complex pathological process, necessitating a comprehensive understanding of intrinsic procedures for ensuring optimal treatment and recovery conditions. Vascular...
KEY FINDING: Endogenous angiogenesis, while triggered by SCI and ischemia, is frequently inadequate to address the progressive local ischemia and cell death.
Biochem Biophys Res Commun, 2018 • February 19, 2018
This study investigates the role of Wnt/β-catenin signaling in fibrotic scar formation following spinal cord injury (SCI) in adult mice using a compression-SCI model and TOPgal reporter mice. The resu...
KEY FINDING: Wnt/β-catenin signaling reporter TOPgal positive cells appeared at the lesion site by 5 days, peaked on 7 days, and diminished by 14 days post injury.
Scientific Reports, 2019 • January 17, 2019
We considered SCI-induced inflammatory mediators as a type of toxin that inhibits the regeneration of injured tissue/cells, and we identified the associated genes and interacting proteins from known b...
KEY FINDING: Tumor necrosis factor (TNF) had the highest scores, and the top 30 were adopted as core data.
Scientific Reports, 2025 • January 29, 2025
This study uses a transcriptomic approach to investigate the mechanisms by which photobiomodulation (PBM) exerts its effects on spinal cord injury (SCI) in rats. The findings indicate that PBM promote...
KEY FINDING: PBM treatment resulted in 1275 differentially expressed genes (DEGs), with 397 upregulated and 878 downregulated, indicating a significant change in gene expression patterns after PBM.
Neural Regeneration Research, 2022 • March 1, 2022
Traumatic spinal cord injuries (SCI) disrupt the connection between the brain and spinal cord neurons, leading to impaired movement. Axon regeneration has been considered the Holy Grail in SCI researc...
KEY FINDING: Netrin-1 promotes significant regeneration of axonal tracts localized at the white matter segment across the transected area.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
The Rehabilomics framework is a translational model that provides an “-omics” overlay to the scientific study of rehabilitation processes and multidimensional outcomes, offering novel opportunities to...
KEY FINDING: Biomarkers can characterize pathophysiology during rehabilitation and recovery, and interrelationships between biomarkers and other innate factors can influence long-term functional outcome, disability and recovery path.
Journal of Nanobiotechnology, 2025 • January 22, 2025
This study engineered a methylprednisolone substitution lipid nanoparticle (MP-LNP) encapsulating C3 transferase mRNA (MP-LNP-C3) for SCI treatment. The MP-LNP effectively transfected neurons and achi...
KEY FINDING: The incorporation of C3 transferase mRNA into MP-LNPs does not compromise the structural integrity of the nanoparticles, ensuring efficient mRNA expression within the spinal cord.