Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,911-3,920 of 11,526 results
Brain Communications, 2021 • November 13, 2021
Axonal regeneration in the mature CNS is limited by extracellular inhibitory factors. Following dorsal column lesions in mice and optic nerve crushes in rats, elevated levels of extracellular histone ...
KEY FINDING: Elevated levels of histone H3 were detected in human CSF 24 h after spinal cord injury.
AGING, 2021 • November 12, 2021
This study investigates the role of RIP3-induced JNK signaling in chronic constriction injury (CCI)-induced neuropathic pain. The findings demonstrate that RIP3 inhibition alleviates neuropathic pain ...
KEY FINDING: RIP3 inhibitors (GSK’872) and JNK inhibitors (SP600125) alleviated pain and reduced inflammatory factor levels in CCI rats.
Neural Regeneration Research, 2022 • November 12, 2021
This study investigates the effect of oscillating field stimulation (OFS) on axonal regeneration, astrocyte proliferation, and astrocyte reorientation after spinal cord injury (SCI), as well as the re...
KEY FINDING: Continuous OFS for more than 6 weeks effectively promotes motor function recovery in rats with spinal cord injury.
Science, 2021 • November 12, 2021
The immune system is implicated in the neurodegenerative process of Lewy body dementia. T cells home to the LBD brain and reside in close proximity to α-synuclein deposits. In conclusion, these result...
KEY FINDING: T cells are located in close proximity to Lewy bodies and dopaminergic neurons in the brains of individuals with LBD.
Science, 2021 • November 12, 2021
This study explores the use of peptide amphiphile supramolecular polymers with two distinct signals to promote recovery from spinal cord injury (SCI) in a mouse model. By tuning the internal motions o...
KEY FINDING: Intensifying molecular motions within bioactive scaffolds, achieved through specific mutations, significantly enhances recovery from spinal cord injury in mice.
Neural Regeneration Research, 2022 • November 12, 2021
The study investigated the neuroprotective potential of APP96-110 peptide, alone and in combination with human mesenchymal stromal cells (hMSCs), following spinal cord injury (SCI) in rats. While APP9...
KEY FINDING: mAPP96-110 alone, and APP96-110 in combination with both viable and non-viable hMSCs significantly reduced cyst size compared to SCI alone.
Biomolecules, 2021 • November 10, 2021
The review focuses on how thrombin modulates Schwann cell pro-regenerative capacities through PAR1 after peripheral nerve injury. Besides thrombin, other proteases like FXa, FVIIa, APC, plasmin, and M...
KEY FINDING: Low levels of thrombin enhance peripheral nerve regeneration after crush injury, whereas high concentrations have detrimental effects.
International Journal of Molecular Sciences, 2021 • November 7, 2021
This review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins. The most important clinical application of L...
KEY FINDING: UFH, LMWH, and synthetic pentasaccharides are used to prevent and cure thromboembolic events, but UFH is also a modulator of cell adhesion, migration, communication, proliferation, and differentiation.
Sensors, 2021 • November 6, 2021
This study introduces a sensor-based gait analysis algorithm designed specifically for SCI patients, utilizing shank-mounted inertial sensors and personalized thresholds for step and gait event detect...
KEY FINDING: The sensor-based algorithm performs similarly well for both SCI patients and healthy controls.
Scientific Reports, 2021 • November 4, 2021
The study aimed to enhance the differentiation potential of hEnSCs into MN-like cells and axonal elongation using the signaling molecules sonic hedgehog (SHH) and retinoic acid (RA), and also by provi...
KEY FINDING: The collagen hydrogel containing EpoB microspheres significantly improved the differentiation of hEnSCs into motor neuron-like cells.