Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 3,931-3,940 of 11,526 results
NEURAL REGENERATION RESEARCH, 2021 • November 1, 2021
This study investigates the use of a decellularized optic nerve (DON) scaffold seeded with neurotrophin-3 (NT-3)-overexpressing Schwann cells (SCs) to promote directional axon regeneration and remyeli...
KEY FINDING: Porcine decellularized optic nerve (DON) scaffolds exhibit uniformly distributed straight channels and microscopic pores, conducive to neural stem cell adhesion, survival, and migration.
Exp Neurol., 2021 • November 1, 2021
This study demonstrates that lentivirus-mediated Nkx6.1 expression promotes cell proliferation and activation of endogenous NSPCs, which correlates with a transient upregulation of the Notch signaling...
KEY FINDING: Nkx6.1 expression increases NSPC activation and proliferation in the acute phase of SCI.
Neurol Neuroimmunol Neuroinflamm, 2021 • November 1, 2021
The study demonstrates that teriflunomide (TF) enhances oligodendroglial differentiation in vitro at nanomolar concentrations, both on neonatal and adult purified OPCs in cultures, an effect mediated by a...
KEY FINDING: Teriflunomide (TF) promotes the differentiation of neonatal and adult mouse oligodendrocytes at nanomolar concentrations.
Expert Reviews in Molecular Medicine, 2021 • November 1, 2021
This review discusses the decellularisation of the brain and spinal cord as well as recellularisation of acellular matrix and the recent progress in the utilisation of brain and spinal cord dECM. The ...
KEY FINDING: dbECM scaffolds induced a strong angiogenic response, comparable to fibroblast growth factor-2 (FGF-2), an angiogenic cytokine.
Annals of Rehabilitation Medicine, 2021 • October 31, 2021
This study developed and evaluated a Korean version of a hospital-based transitional rehabilitation program (TRP) for spinal cord injury (SCI) patients, utilizing a daily living home (DLH) to simulate...
KEY FINDING: The Korean version of the Spinal Cord Independence Measure showed functional improvement at the end of TRP, when compared to that before the TRP (49.3±6.9 vs. 62.5±6.0; p<0.05).
Cells, 2021 • October 30, 2021
This review provides a detailed overview of the local and systemic alterations due to TSCI and TBI, which severely affect multiple physiological systems. It raises awareness of the impact of TSCI–TBI ...
KEY FINDING: TSCI and TBI interact bidirectionally, impacting cognitive and sensorimotor outcomes.
Cells, 2021 • October 29, 2021
The study investigates the role of transglutaminase 2 (TG2) in astrocytes following spinal cord injury (SCI) using a mouse model with astrocyte-specific TG2 deletion (TG2-A-cKO). Deletion of TG2 in as...
KEY FINDING: Deletion of TG2 from astrocytes resulted in a significant improvement in motor function following SCI.
Brain Sci., 2021 • October 28, 2021
This study compared the effectiveness of unified alternate gait training (AGT) using knee-ankle-foot orthoses (KAFOs) with traditional gait training in hemiplegic stroke patients. The results showed t...
KEY FINDING: The FIM gait score significantly increased in the AGT subjects compared to their initial score at 1, 2, and 3 months.
Brain Sci., 2021 • October 28, 2021
This study investigated the effects of whole-body extremely low-frequency electromagnetic field (EMF) stimulation on nociception and sensorimotor deficits in rats with complete thoracic spinal cord in...
KEY FINDING: EMF stimulation significantly attenuated hyperalgesia and allodynia to thermal, electrical, and chemical stimuli from 6 weeks onwards in rats with complete SCI.
Central European Journal of Urology, 2021 • October 28, 2021
This study investigated the use of gabapentin as an add-on therapy for patients with spinal cord injury who have neurogenic overactive detrusor that is unresponsive to combined anticholinergic and bet...
KEY FINDING: In 11 patients (40.17%), gabapentin add-on therapy led to decreased detrusor contractions, maximal detrusor pressure, and the number of incontinence episodes.