Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,001-4,010 of 11,526 results
eLife, 2021 • September 29, 2021
This study performed single-cell transcriptional profiling of mouse DRG in response to peripheral and central axon injuries. The study provides a map of the distinct DRG microenvironment responses to ...
KEY FINDING: Each cell type in the DRG microenvironment responds differently to peripheral (sciatic nerve crush), dorsal root crush, and spinal cord injuries.
The EMBO Journal, 2021 • September 29, 2021
This study investigates the role of DNA methylation in epidermal homeostasis by deleting Dnmt1 in mouse epidermis using Keratin 5-Cre (K5-Cre). The results show that DNMT1 ablation triggers a strong p...
KEY FINDING: Epidermis-specific deletion of DNMT1 disrupts epidermal structure and homeostasis, initiating a massive innate immune response and infiltration of immune cells.
The Journal of Neuroscience, 2021 • September 29, 2021
This study investigates the role of Akt in oligodendrocyte (OL) development using OL lineage cell-specific Akt triple-conditional knock-out (Akt cTKO) mice. The researchers found that loss of total Ak...
KEY FINDING: Deletion of Akt three isoforms in oligodendrocyte lineage cells causes a complete loss of mature oligodendrocytes in the CNS.
Journal of Orthopaedic Translation, 2021 • September 28, 2021
In particular, exosomal miRNA has been shown to regulate protein expression in recipient cells and have functional role in vivo. It has been reported that treatment by exosomes in the early stage afte...
KEY FINDING: MSCs derived exosomes containing genetic materials (such as miRNA-486, miRNA-21, miRNA-133b, and miRNA-126 et al.) can be used as a cell-free treatment strategy, which have great potential to promote functional recovery, and their contents can be used as biomarkers of SCI.
Cells, 2021 • September 28, 2021
This study investigated the restorative effects of human amniotic fluid mesenchymal stem cells (hAF-MSCs) and their conditioned medium (CM) on spinal cord injury (SCI) in a rat model. The results demo...
KEY FINDING: hAF-MSCs increased the expression of doublecortin (DCX), a marker of neurogenesis, significantly more than the injury group, indicating enhanced nerve regeneration.
Frontiers in Cellular Neuroscience, 2021 • September 28, 2021
This study investigates the therapeutic potential of bone marrow mesenchymal stem cell-derived exosome-educated macrophages (EEM) in promoting functional healing after spinal cord injury (SCI). The fi...
KEY FINDING: EEM treatment effectively promoted the angiogenic activity of HUVECs and axonal growth in cortical neurons in vitro.
Behavior Research Methods, 2022 • September 28, 2021
The study introduces a 3D LIVE-streaming technique to create full-body illusions, addressing limitations of head-mounted displays in neuroscience research. The method involves capturing and streaming ...
KEY FINDING: The average reported displacement towards the projected image was 69.1 cm in Session 1 and 72.4 cm in Session 2, confirming the effectiveness of the novel FBI-paradigm.
Brain Sciences, 2021 • September 28, 2021
This study examined the effects of end-effector robot-assisted gait training (RAGT) on motor function, proprioception, balance, and gait ability in patients with incomplete spinal cord injury (SCI). T...
KEY FINDING: End-effector RAGT significantly improved gait speed (10MWT) and endurance (6mWT) in SCI patients.
North American Spine Society Journal, 2021 • September 28, 2021
This meta-analysis of 74 case reports and series characterizes iatrogenic spinal cord ischemia (ISCI), evaluates treatment strategies, and compares outcomes based on infarction location. The study rev...
KEY FINDING: Non-aortic surgeries were associated with significantly poorer overall outcomes compared to aortic and endovascular surgeries.
Biology, 2021 • September 28, 2021
Neuroplasticity is a robust mechanism by which the central nervous system attempts to adapt to a structural or chemical disruption of functional connections between neurons. Following damage to nervou...
KEY FINDING: Spontaneous plasticity of the spared components of the CST is a compensatory mechanism underlying forelimb motor recovery, as opposed to the restoration and/or regeneration of the damaged motor tract.