Latest Research Summaries

KEY FINDING: Three distinct sub-groups of people with SCI were identified: participants with spasticity and corticospinal responses in the quadriceps femoris and soleus muscle, participants with spasticity and corticospinal responses in the quadriceps femoris muscle only, and participants with no spasticity or corticospinal responses in either muscle.

KEY FINDING: All three methods for creating the crosswalk (expert panel, equipercentile, and Rasch analysis) resulted in strong correlations between the original scores and the converted scores.

KEY FINDING: The spine generic protocol provides a harmonized approach for acquiring high-quality qMRI of the human cervical spinal cord at 3T across the three main MRI manufacturers.

KEY FINDING: Muscle loss after SCI is more rapid than in other disuse conditions, with distinct molecular signaling cascades.

KEY FINDING: Damage is predominantly in the grey matter (GM) of the spinal cord across most animal models.

KEY FINDING: Early surgical treatment of patients with chronic lumbar radiculopathy (defined as symptoms of 4 to 12 months duration) was cost-effective

KEY FINDING: The error in Figure 6(a) involved mislabeling of simulated groups in the EO and EC conditions.

KEY FINDING: SPPPs reduced shoulder pain onset prevalence regardless of instruction format. SP onset was identical in the two SPPPs but was significantly lower at 18 and 36 months in both groups compared to controls.

KEY FINDING: Exosomes can be effectively loaded with miR-494 using chemical transfection, resulting in a high loading rate and stability, protecting the miRNA from degradation in the body.

KEY FINDING: SCS acts as a prosthetic, enabling individuals to move previously paralyzed limbs from the first day of implantation.