Browse our collection of 11,526 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 4,061-4,070 of 11,526 results
Spinal Cord Series and Cases, 2021 • September 7, 2021
The study investigated changes in body composition in individuals with recent SCI during inpatient rehabilitation and up to one year post-discharge. Body composition remained relatively stable during ...
KEY FINDING: During inpatient rehabilitation, no significant changes in all body composition parameters were found.
Cells, 2021 • September 5, 2021
Human iPSCs have become a powerful tool in basic as well as translational and clinical research because of their ability to be maintained indefinitely whilst preserving the genetic makeup of the host. ...
KEY FINDING: iPSC-based disease models have been studied for cardiac channelopathies including hereditary long QT syndrome (LQTS), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC).
Cell Death and Disease, 2021 • September 3, 2021
This study profiles transcriptomes and proteomes in a mouse model of AMI, revealing early immune system activation and pyroptosis. VX-765, a pyroptosis inhibitor, reduced infarct size and improved hea...
KEY FINDING: Immune system activation and subsequent pyroptosis occur in the early stages (6-24 hours) of AMI in a mouse model.
J Neurosurg Spine, 2021 • September 3, 2021
This study presents a CGMP-compliant method for manufacturing autologous Schwann cells (SCs) for clinical use in treating spinal cord injuries (SCIs), peripheral nerve injuries (PNIs), and other condi...
KEY FINDING: The study produced an average yield of 87.2 ± 89.2 million cells at passage 2 (P2) and 150.9 ± 129.9 million cells at passage 3 (P3) with high viability and purity.
Journal of Neuroinflammation, 2021 • September 2, 2021
This study investigates the role of Heat shock transcription factor 1 (HSF1) in suppressing the conversion of A1 astrocytes following spinal cord injury (SCI) in rats. The results showed that HSF1 pro...
KEY FINDING: HSF1 protein levels increase in astrocytes after spinal cord injury in rats, showing colocalization with astrocytes at lesion sites.
Oxidative Medicine and Cellular Longevity, 2021 • September 1, 2021
This study investigates the role of mitochondrial ROS in mechanical stress-induced disc degeneration using a one-strike loading organ culture model. The researchers found that mechanical stress leads ...
KEY FINDING: Mechanical stress induces mitochondrial dysfunction and ROS accumulation in nucleus pulposus (NP) cells. The proportion of ROS-positive cells increased significantly in the first 12 hours after mechanical stress.
Brazilian Journal of Medical and Biological Research, 2021 • September 1, 2021
This study aimed to determine the effects of Nogo-A and its receptor on sciatic nerve repair in rats. Rats were divided into control, model (sciatic nerve transection), immediate repair, and delayed r...
KEY FINDING: The expression of Nogo-A and its receptor, NgR, significantly increased in the spinal cord and sciatic nerve tissues after sciatic nerve transection in rats.
J Korean Neurosurg Soc, 2021 • September 1, 2021
The study aimed to identify the ideal expression ratio of the Wnt3a gene transfected into MSC to maximize neuro-regenerative effects in a chronic rat SCI model. The results showed that enhanced gene e...
KEY FINDING: Enhanced gene expression of Wnt3a in hMSC can potentiate axonal regeneration and improve functional recovery in a rat model of chronic SCI.
Glia, 2021 • September 1, 2021
This study investigates the potential of hypoxia-mimetics, specifically deferoxamine (DFO) and adaptaquin (AQ), to protect Schwann cells (SCs) against oxidative stress-induced cell death, a significan...
KEY FINDING: Hypoxia-mimetics DFO and AQ enhance HIF-1α stability and HIF-1α target gene expression in Schwann cells.
Neural Regeneration Research, 2021 • September 1, 2021
Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Recent discoveries on the innate immune system ability to modulate stem cells f...
KEY FINDING: An acute and transient inflammation response is necessary to induce stem cell proliferation.