Browse the latest research summaries in the field of dermatology for spinal cord injury patients and caregivers.
Showing 121-130 of 158 results
Cell Tissue Res., 2022 • March 1, 2022
CNS fibrosis is no longer considered limited to penetrating injuries involving meningeal fibroblasts. Perivascular fibroblasts can form fibrotic scars in closed injuries like EAE or stroke, influenced...
KEY FINDING: Fibrotic scars in the CNS can originate from the perivascular niche, specifically from perivascular fibroblasts, even when the meninges remain intact after injury.
Theranostics, 2021 • July 25, 2021
The study demonstrates the self-assembly of skin progenitor cells into vascularized spheroid floating skin organoids (FSOs) in vitro and properly stratified rapidly vascularized human skin in vivo. Hu...
KEY FINDING: Adult and iPSC-derived fibroblasts, keratinocytes, and endothelial progenitors can self-assemble into both planar human skin in vivo and spheroid-shaped skin organoids in vitro.
Journal of Immunology Research, 2022 • February 3, 2022
This study investigates the potential of ADSC-Exos as a cell-free therapeutic strategy for immune-mediated alopecia by examining their effects on hair growth both in vitro and in vivo. The results dem...
KEY FINDING: ADSC-Exos significantly promoted DPC proliferation and migration while also reducing apoptosis in vitro.
Frontiers in Genetics, 2022 • July 12, 2022
In this study, in total, sixteen variants were detected in twelve OCA cases including fourteen recurrent variants and two novel variants. In summary, we reported sixteen different variants in twelve O...
KEY FINDING: Ten TYR-related and two OCA2-related patients were identified with 16 different variants with potential pathogenicity.
Stem Cell Research & Therapy, 2022 • January 1, 2022
This study explored the potential clinical application roles of hADSCs-Exos encapsulated in functional PF-127 hydrogel in wound healing. The hADSCs-Exos/PF-127 combination could promote wound healing ...
KEY FINDING: PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased expression of Ki67, α-SMA, and CD31, facilitated collagen synthesis (Collagen I, Collagen III), up-regulated expression of skin barrier proteins (KRT1, AQP3), and reduced inflammation (IL-6, TNF-α, CD68, CD206).
Pharmaceuticals, 2022 • December 19, 2022
This study explored the potential of Andrographolide (Andro) to alleviate post-operative pain in a rat model. The results showed that Andro, when administered via direct injection, significantly reduc...
KEY FINDING: Andro injections significantly reduced mechanical allodynia (pain from a stimulus that doesn't normally cause pain) compared to saline treatment.
Int. J. Mol. Sci., 2023 • March 8, 2023
This study introduces a novel fluorescence-based screening system for gene editing molecules targeting junctional epidermolysis bullosa (JEB). The research team successfully created a cell line that e...
KEY FINDING: The researchers successfully generated a cell line expressing a GFP-C17 fusion protein, allowing for real-time monitoring of COL17A1 expression and localization.
Bioactive Materials, 2023 • April 2, 2023
This review provides a comprehensive overview of microneedle systems, including potential cargos, structural designs, material selection, and drug release mechanisms. The review summarizes different m...
KEY FINDING: Microneedles can easily pass through physical barriers at wound sites and sustainably release drugs, enhancing drug delivery efficiency.
Frontiers in Medicine, 2024 • January 5, 2024
The study confirmed the efficacy and safety of MPPT in treating acute and chronic wounds, including those with antimicrobial-resistant infections, in immunocompromised individuals with SCI. MPPT treat...
KEY FINDING: All acute and chronic grade 1–4 wounds and pressure ulcers in SCI patients achieved stable closure with MPPT treatment.
STEM CELLS TRANSLATIONAL MEDICINE, 2016 • July 7, 2016
The study investigates the role of umbilical cord-derived mesenchymal stem cells (uMSCs) in scar formation during wound healing, finding that uMSCs reduce scar formation and myofibroblast accumulation...
KEY FINDING: uMSCs reduced scar formation and myofibroblast accumulation in a skin-defect mouse model.