Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 131-140 of 211 results
Frontiers in Endocrinology, 2022 • February 17, 2022
This study comprehensively examined and elucidated the pharmacological and physiological regulation of central melanocortin signaling in the axolotl. The study found a relatively conserved protein str...
KEY FINDING: Axolotl MC3R and MC4R can be activated by a-MSH and ACTH. Axolotl MC3R exhibited a high constitutive activity, that was significantly decreased by MRAP2
BMJ Open, 2022 • September 14, 2022
This study protocol outlines a randomized clinical trial to investigate the effects of testosterone treatment (TT) combined with long pulse width stimulation (LPWS) on denervated muscles in individual...
KEY FINDING: The study hypothesizes that TT+LPWS will upregulate protein synthesis pathways, downregulate protein degradation pathways, and increase overall mitochondrial health in denervated muscles.
bioRxiv, 2023 • February 27, 2023
This study investigates the role of DOCK3 in skeletal muscle using a muscle-specific knockout mouse model. The researchers found that loss of DOCK3 in skeletal muscle leads to impaired muscle regenera...
KEY FINDING: Dock3 mKO mice presented with significant hyperglycemia and increased fat mass, indicating a metabolic role in the maintenance of skeletal muscle health.
International Journal of Biological Sciences, 2023 • July 9, 2023
This study demonstrates that purinergic receptor P2Y12 (P2RY12) plays a significant role in boosting autoimmune hepatitis (AIH) through hexokinase 2 (HK2)-dependent glycolysis in T cells. The research...
KEY FINDING: P2RY12 deficiency protects mice from ConA-induced immune hepatitis by reducing serum ALT and AST levels, blocking the increases of serum IFN-γ, IL-12p70, IL-6, and TNF-α, and decreasing serum IL-10.
Metabolites, 2023 • August 3, 2023
The study investigates the efficacy of combining a ketogenic diet (KD), metformin (MET), and metronomic cyclophosphamide (CP) as a triple therapy for MYCN-amplified neuroblastoma (NB). Results showed ...
KEY FINDING: MET reduces cell proliferation and mitochondrial respiration in MYCN-amplified NB cell lines.
Am J Case Rep, 2015 • October 27, 2015
This case report investigated the neuroregenerative potential of oxandrolone in a patient with Charcot-Marie-Tooth disease type 1 (CMT1). The patient received oxandrolone and underwent exercise traini...
KEY FINDING: The patient gained 5.0 kg of lean body mass after the 3-month therapy.
Frontiers in Endocrinology, 2023 • November 8, 2023
This study employed Mendelian randomization to investigate the causal relationship between sarcopenic obesity (SO) factors and benign prostatic hyperplasia (BPH), focusing on basal metabolic rate (BMR...
KEY FINDING: An increase in BMR is associated with an elevated risk of developing BPH.
JCI Insight, 2024 • March 7, 2024
This study evaluated the therapeutic potential of nicotinamide riboside (NR) supplementation in a transgenic mouse model of spinal and bulbar muscular atrophy (SBMA). The researchers aimed to increase...
KEY FINDING: NR supplementation failed to ameliorate motor dysfunction or muscle pathology in a transgenic mouse model of SBMA.
Frontiers in Endocrinology, 2024 • May 10, 2024
This study uses Mendelian randomization (MR) to explore the causal relationships between hormonal and reproductive factors (ANM, AAM, LMC, AFB, AFS, ALB) and the prevalence of low back pain (LBP). The...
KEY FINDING: AAM (OR=0.784, 95% CI: 0.689-0.891; p=3.53E-04), AFB (OR=0.558, 95% CI: 0.436-0.715; p=8.97E-06), ALB (OR=0.396, 95% CI: 0.226-0.692; p=0.002), and AFS (OR=0.602, 95% CI: 0.518-0.700; p=3.47E-10) were associated with a decreased risk of LBP.
Metabolic Brain Disease, 2024 • July 9, 2024
This study used lipidomics and metabolomics to investigate lipid and metabolite changes in the spinal cords of diabetic rats with painful neuropathy. The results showed dysregulation of 170 metabolite...
KEY FINDING: Dysregulation of 170 metabolites and 45 lipids was observed in the spinal cords of rats with painful diabetic neuropathy (PDN).