Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 161-170 of 211 results
Dev Neurobiol, 2017 • October 1, 2017
This study explores the role of estrogen signaling in exercise-mediated enhancement of motoneuron participation in axon regeneration after peripheral nerve injury in mice. The results indicate that bo...
KEY FINDING: Treadmill training and estradiol administration both increased motoneuron participation in axon regeneration.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This cross-sectional study assessed dyslipidemia management in men with chronic SCI according to NCEP guidelines, revealing suboptimal treatment and control rates, particularly in intermediate- and hi...
KEY FINDING: Dyslipidemia was present in 39.5% of the men with chronic SCI.
Advanced Science, 2023 • November 24, 2022
This review summarizes the microenvironmental characteristics of DFU, presents the main progress of wound healing, and summaries the state-of-the-art therapeutic strategies for DFU. The DFU clinical t...
KEY FINDING: The review highlights the complex microenvironment of DFUs, characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and high protease activity, all hindering the normal wound healing process.
J Mol Endocrinol, 2022 • November 1, 2022
Retinoic acid (RA) signaling, mediated by nuclear RA receptors (RARs), is crucial for embryonic development. RA's role was discovered through observations of its teratogenic effects and later confirme...
KEY FINDING: RA signaling is required for normal early development of many organs and tissues, including the hindbrain, posterior body axis, somites, spinal cord, forelimbs, heart, and eye.
World J Orthop, 2015 • September 18, 2015
The editorial introduces different adipose tissue types and establishes a scientific basis to develop interventions to manage adiposity after spinal cord injury (SCI). It summarizes available evidence...
KEY FINDING: Individuals with tetraplegia tend to accumulate greater leg fat mass compared to those with paraplegia, but have a lower ratio of trunk fat mass to whole-body fat mass.
Annals of Rehabilitation Medicine, 2016 • December 1, 2016
This study investigated the incidence of adrenal insufficiency (AI) in spinal cord injury (SCI) patients presenting with AI-like symptoms, particularly in relation to large-dose glucocorticoid treatme...
KEY FINDING: A significant portion (41.4%) of SCI patients with AI-like symptoms were diagnosed with AI based on ACTH stimulation tests.
International Journal of Molecular Sciences, 2018 • June 7, 2018
SCI leads to muscle loss and impaired mitochondrial function, partly due to increased FOXO signaling and reduced PGC-1α/β expression. Testosterone promotes muscle anabolism and anticatabolic effects, ...
KEY FINDING: Low testosterone levels are common after SCI and may exacerbate muscle loss and neuromuscular impairment.
Frontiers in Endocrinology, 2022 • June 30, 2022
This study investigates the role of CD137 in age-related bone loss and senile osteoporosis. Through bioinformatics analysis of gene expression datasets, CD137 was identified as a potential key gene in...
KEY FINDING: Aged mice (18-month-old) exhibited significant bone loss compared to young mice (6-month-old), along with a tenfold increase in adipose tissue in the bone marrow cavity.
Journal of Molecular Medicine, 2020 • December 20, 2019
This study investigates the role of platelet-derived factors on placental βhCG synthesis. It demonstrates that maternal platelets can be detected at the early maternal-fetal interface and that platele...
KEY FINDING: Maternal platelets can be detected on the surface of placental villi and in intercellular gaps of trophoblast cell columns from gestational week 5 onwards.
The Journal of Spinal Cord Medicine, 2019 • July 1, 2019
This study investigated the influence of sex on adipose tissue distribution and its relationship with inflammatory adipokines and cardiometabolic profiles in individuals with motor complete spinal cor...
KEY FINDING: Male participants with SCI had significantly greater visceral adipose tissue (VAT) volume and VAT:SAT ratio compared to females.