Browse the latest research summaries in the field of endocrinology for spinal cord injury patients and caregivers.
Showing 151-160 of 211 results
Frontiers in Neuroscience, 2020 • December 17, 2020
This review examines the potential of endocrine therapy for spinal cord injury (SCI) treatment. It discusses the neuroprotective roles of estrogen, testosterone, erythropoietin (EPO), basic fibroblast...
KEY FINDING: Estrogen exhibits neuroprotective effects by reducing oxidative stress, cell death, and inflammation in neurodegenerative diseases and SCI. It activates neuroprotective signaling pathways and promotes the expression of anti-apoptotic factors.
Scientific Reports, 2021 • January 27, 2021
This study investigates the potential neuroprotective role of calcitonin gene-related peptide (CGRP) in diabetic peripheral neuropathy (DPN) using a rat model. The researchers found that dietary capsa...
KEY FINDING: Dietary capsaicin in diabetic rats preserved nociceptive sensation and CGRP levels in the spinal cord and DRG neurons.
Frontiers in Cellular Neuroscience, 2021 • March 8, 2021
The review summarizes the roles of endogenous estrogens, estrogen-based therapies, and estrogen-like molecules on brain homeostasis, especially regarding neurogenesis, gliogenesis, and neuroprotection...
KEY FINDING: Estrogens, including estradiol, promote survival in neurons subjected to stress conditions and may counteract aging-associated cognitive decline and prevent Alzheimer’s disease.
Frontiers in Cell and Developmental Biology, 2021 • March 25, 2021
This review explores the potential of ghrelin as a therapeutic molecule for nervous system injuries. Ghrelin's ability to cross the blood-brain barrier and influence multiple physiological processes m...
KEY FINDING: Ghrelin can modulate downstream signaling cascades in both the developing and adult nervous systems, influencing neurogenesis and neuronal plasticity.
Frontiers in Endocrinology, 2012 • February 7, 2012
This study establishes that DHEA is biosynthesized in the developing ventral neural tube at the time of neurogenesis and cell fate determination. In in vitro models, DHEA modulated the induction of ex...
KEY FINDING: DHEA induces the expression of class II protein Nkx6.1, motor neuron precursor Olig-2, and definitive motor neuron marker Isl-1/2 in vitro.
Neuroscience, 2013 • June 3, 2013
This review examines the influence of androgens on BDNF signaling within neuromuscular systems and suggests a mechanism for the trophic effects of androgens on spinal motoneurons through the androgeni...
KEY FINDING: Androgens regulate BDNF and trkB expression (the receptor for BDNF) in spinal motoneurons, influencing their morphology.
The Journal of Neuroscience, 1989 • April 1, 1989
This study investigated the role of the medullary pacemaker nucleus (PMN) in electroreceptor tuning plasticity in Sternopygus macrurus. The researchers examined hormone-mediated shifts and the develop...
KEY FINDING: The PMN is not necessary for the hormone-mediated shift of electroreceptor tuning.
The Journal of Neuroscience, 1986 • May 1, 1986
This study demonstrates the presence of androgen receptors in hypoglossal, facial, and cochlear nuclei, and tongue muscles of adult rats, using in vitro binding assays with a synthetic ligand, R1881. ...
KEY FINDING: Hypoglossal nuclei have higher levels of androgen receptors (8.9 fmol/mg protein) than facial (4.8 fmol/mg protein) or cochlear nuclei (4.0 fmol/mg protein).
Cellular and Molecular Neurobiology, 1996 • January 1, 1996
During the prenatal period, gonadal steriod environment induces dramatic sexually dimorphic changes in the nervous system. We have used in vitro methods to study the mechanism and timing of hormonal i...
KEY FINDING: Estrogen (17β estradiol) enhances sprouting of hypothalamic neuronal fibers.
Trials, 2019 • September 5, 2019
This study investigates the effects of an 8-week low-carbohydrate/high-protein (LC/HP) dietary intervention on metabolic health, body composition, gut bacteria composition, and quality of life in indi...
KEY FINDING: The study aims to determine if a low-carbohydrate/high-protein diet improves glucose tolerance, insulin sensitivity, and β-cell function in individuals with SCI.