Genetics Research

KEY FINDING: Hsa_circ_0026646 was identified as a core circRNA upregulated in SCI, potentially acting as a 'molecular sponge' for miR-331-3p.

KEY FINDING: At the respiratory level, tissue damage is notable in situations that require increased ventilation due to lower thoracic distensibility and alveolar inflammation caused by higher levels of leptin as a result of increased fatty tissue.

KEY FINDING: FMT treatment significantly improved spinal cord tissue sparing, vascular perfusion, and BSCB integrity in SCI mice.

KEY FINDING: Nine phages were identified that individually decreased cell viability by >80% when added to biofilms of two E. coli strains in human urine.

KEY FINDING: Notch1 mRNA expression trended toward a significant increase from Pre to 2 Days post-muscle damage from baseline measures (p = 0.087).

KEY FINDING: Overexpression of FANCC suppressed microglial pyroptosis by inhibiting p38/NLRP3 expression, which in turn reduced neuronal apoptosis.

KEY FINDING: Sodium selenite treatment decreased iron concentration and levels of the lipid peroxidation products malondialdehyde and 4-hydroxynonenal in a rat model of spinal cord injury.

KEY FINDING: SCS significantly increased the mechanical withdrawal threshold in CCI rats, indicating pain relief.

KEY FINDING: Sustained microglial depletion would aggravate injury and impair functional recovery after spinal cord injury.

KEY FINDING: Perineural DEX significantly reversed the decline in mechanical threshold and thermal latency in CCI mice, indicating pain relief.