Genetics Research

KEY FINDING: xtMc1r interacts directly with xtMrap1 and xtMrap2 proteins on the plasma membrane, validated through co-immunoprecipitation and fluorescence.

KEY FINDING: MCM-mediated mRNA delivery is an efficient non-viral gene delivery method in primary neural cells in vitro and enabled localized transgene expression in the glial scar in vivo.

KEY FINDING: The inflammatory response was increased at 1 hour and 1 day after SCI, while the integral component of the synaptic membrane was increased at 1 day.

KEY FINDING: The study identified 76 differentially expressed lncRNAs (DELs), 33 differentially expressed miRNAs (DEMs), and 30 differentially expressed genes (DEGs) between SCI rats and exercise therapy rats.

KEY FINDING: D-DT protein levels were significantly elevated within neurons and astrocytes following SCI, suggesting these cell types are crucial sources of D-DT production following SCI.

KEY FINDING: After SCI, significantly fewer oligodendrocytes were observed, while NRP1 and its ligand Sema3A were upregulated.

KEY FINDING: Following spinal cord injury, primary mechanical trauma can cause cell swelling and lysis, increasing the extracellular Ca2+ concentration, leading to excitotoxicity.

KEY FINDING: miR-21 overexpression reduces neuroinflammation after SCI by decreasing the expression of inflammatory factors.

KEY FINDING: Four out of 15 participants experienced an adverse event, including gastrointestinal distress and elevated liver enzymes, leading to three subjects discontinuing the medication.

KEY FINDING: Neurologically motor-complete SCI causes loss of bone mass and deterioration of trabecular bone microstructure as early as 2 days after injury.