Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 141-150 of 1,651 results
Scientific Reports, 2019 • November 5, 2019
This study evaluated the efficacy of fenofibrate monotherapy on the lipoprotein profile of persons with SCI. The intervention had a robust effect to produce favorable changes to the serum TG, HDL-C an...
KEY FINDING: Fenofibrate treatment resulted in a 40% reduction in serum triglyceride (TG) concentration after both 2 and 4 months.
Neural Regen Res, 2020 • December 10, 2019
This meta-analysis aimed to evaluate the effects of autophagy regulation on spinal cord injury (SCI) in rats through direct and indirect comparisons of relevant studies. The study found that both upre...
KEY FINDING: Upregulation of autophagy significantly elevated Basso, Beattie, and Bresnahan scores at 1 day, 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks after spinal cord injury compared with the control group.
Journal of Neuroinflammation, 2019 • December 10, 2019
This study demonstrates that lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with SCI. The study shows that reducing α-synuclein pr...
KEY FINDING: Downregulation of α-synuclein reduces inflammatory infiltration and preserves myelin after SCI.
The Journal of Clinical Investigation, 2020 • March 16, 2020
Using models with different regenerative capacities, followed by gain- and loss-of-function analysis, we identified profilin 1 (Pfn1) as a coordinator of actin and microtubules (MTs), powering axonal ...
KEY FINDING: Pfn1 activity increases after CL, suggesting it's important for actin dynamics in the axonal tip and for growth competence.
TISSUE ENGINEERING: Part A, 2020 • February 27, 2020
The study investigates the use of polycistronic vectors to co-express IL-10 and NT-3 from a PLG bridge to enhance spinal cord regeneration after injury. The combined delivery of IL-10 and NT-3 resulte...
KEY FINDING: Combined delivery of IL-10 and NT-3 significantly increased axonal density and myelinated axons compared to other conditions.
Nature Communications, 2020 • February 21, 2020
Denervation of skeletal muscles leads to atrophy, marked by cellular changes like increased plasma membrane permeability and accelerated protein catabolism. The study aimed to identify factors prevent...
KEY FINDING: Acetylcholine (ACh) and its analogs repress the expression of connexin43 and connexin45 hemichannels, which are associated with muscle atrophy.
Neurol Genet, 2020 • April 1, 2020
This study provides evidence of genetic influence on spinal cord structure, showing that MRI metrics of cervical spinal cord anatomy are robust and not easily influenced by nonpathological environment...
KEY FINDING: The spinal cord C2 cross-sectional area (CSA), left-right width (LRW), and anterior-posterior width (APW) are highly heritable (85%–91%).
J Transl Med, 2020 • March 14, 2020
This study assessed factors associated with circulating PAMM levels in adults with acute, traumatic SCI and in adults without SCI. Factors associated with PAMM levels varied based on the presence or a...
KEY FINDING: Participants with motor complete SCI showed the greatest change in PAMM levels compared to able-bodied individuals, with a statistically significant difference.
International Journal of Molecular Sciences, 2020 • March 30, 2020
This study evaluated the analgesic effects of spinal cord stimulation (SCS) on neuropathic pain following spared nerve injury (SNI) in rats, focusing on the role of microglial activation and neuronal ...
KEY FINDING: SCS and minocycline both reduced plantar mechanical hypersensitivity in rats after spared nerve injury (SNI), indicating a reduction in pain sensitivity.
Neurosci. Bull., 2020 • April 18, 2020
This study investigates the role of SOCS3 in spinal cord regeneration in geckos, focusing on its impact on inflammation mediated by GM-CSF and IFN-c. The researchers found that SOCS3 expression is upr...
KEY FINDING: Severing the gecko spinal cord did not evoke an inflammatory cascade except for an injury-stimulated elevation of the granulocyte/macrophage colony-stimulating factor (GM-CSF) and interferon gamma (IFN-c) cytokines.