Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 261-270 of 1,651 results
Brain Res, 2016 • May 1, 2016
The reactions of OPCs to spinal cord injury are reviewed. Inflammation after injury can affect OPC biology and OPCX reactivity ma affect the inflammatory response. OPC accumulation after spinal cord i...
KEY FINDING: OPCs are the major dividing cell of the CNS and the injury-induced increases in OPC density are mostly due to proliferation.
Neural Regeneration Research, 2022 • March 1, 2022
This study aimed to determine the function of KLF7 in stretch- and OGD-induced apoptosis of HT22 cells in vitro, and in TBI-induced hippocampal neuron damage in mice in vivo. The results suggest that ...
KEY FINDING: KLF7 overexpression significantly reduced apoptosis, activated caspase-3 and lactate dehydrogenase, downregulated the expression of Bax and cleaved caspase-3, and increased the expression of βIII-tubulin and Bcl-2 in HT22 cells after stretch injury and oxygen-glucose deprivation.
Journal of Extracellular Vesicles, 2025 • January 1, 2025
The study investigates the therapeutic potential of intranasally administered BDNF-loaded small extracellular vesicles (BDNF-sEVs) for acute spinal cord injury (SCI) in rats and monkeys. Results demon...
KEY FINDING: BDNF loading enhances the neurite outgrowth promoted by sEVs in cultured neurons, suggesting an improved neurotrophic effect.
Neurosci Bull, 2015 • October 1, 2015
In this study, we present the fi rst evidence that the TAPP1 adaptor protein is selectively expressed by differentiating OPCs (Fig. 1). Functional analyses revealed that knockdown of TAPP1 expression i...
KEY FINDING: TAPP1 knockdown promoted OL differentiation and myelin gene expression in culture.
The Journal of Neuroscience, 2003 • September 24, 2003
This study investigates the mechanisms of oligodendrocyte death after spinal cord injury (SCI) using wild-type mice, Wlds mice (with delayed Wallerian degeneration), and Bax-deficient mice. The findin...
KEY FINDING: Oligodendrocyte death occurs via apoptosis following spinal cord injury.
CNS Neurosci Ther, 2017 • June 1, 2017
This study aimed to investigate the effects of overexpressing Olig2, a transcription factor involved in myelination, on adult spinal cord injury rats using lentivirus-mediated gene transfer. The resul...
KEY FINDING: Local injection of Lenti-Olig2 significantly increased the number of oligodendrocytes lineage cells and enhanced myelination after SCI.
EMBO Reports, 2021 • August 24, 2021
This study investigates the role of Foxm1, a transcription factor, in spinal cord regeneration in Xenopus tropicalis tadpoles using bulk and single-cell RNA sequencing. The research finds that Foxm1 i...
KEY FINDING: Foxm1 is specifically expressed in the regenerating spinal cord of Xenopus tadpoles, peaking at 3 days post-amputation.
J. Biol. Chem., 2017 • May 2, 2017
This study investigates how muscle-released products interact with bone cells to influence their function, focusing on myostatin's role in muscle-bone interaction. Myostatin directly targets osteocyte...
KEY FINDING: Myostatin increases the expression of SOST, DKK1, and RANKL in osteocytes, which are important regulators in bone remodeling.
Spinal Cord Series and Cases, 2017 • May 11, 2017
This study examined the effects of a wheelchair half marathon on adrenaline, oxidant/antioxidant balance, and oxLDL levels in athletes with cervical (CSCI) and lower (LSCI) spinal cord injuries. The r...
KEY FINDING: OxLDL levels remained stable throughout the study in both LSCI and CSCI subjects, despite adrenaline levels increasing in LSCI athletes after the half marathon.
Neurobiol Dis, 2007 • June 1, 2007
This study investigates the role of spinal microglia in the anti-allodynic and anti-hyperalgesic effects of electroacupuncture (EA) in a rat model of monoarthritis induced by Complete Freund’s Adjuvan...
KEY FINDING: Unilateral intra-articular injection of CFA produced a robust microglial activation and the up-regulation of the tumor necrosis factor (TNF)-α, interleukin (IL-1β), and IL-6 mRNA levels in the spinal cord.