Browse the latest research summaries in the field of genetics for spinal cord injury patients and caregivers.
Showing 271-280 of 1,651 results
Pain, 2008 • July 31, 2008
This study investigated the role of TNF signaling in the development of CRPS-like changes in rats after tibia fracture. The researchers found that TNF expression was upregulated in the hindpaw skin an...
KEY FINDING: Tibia fracture upregulated TNF expression and protein levels in the hindpaw skin and sciatic nerve.
J Spinal Cord Med, 2007 • January 11, 2007
The study examined ECG abnormalities in 43 individuals with chronic SCI and abnormal lipid profiles, finding that ECG abnormalities were common. Injury duration, rather than age, was a significant pre...
KEY FINDING: ECG abnormalities were prevalent in 60.5% of the study participants with SCI and abnormal lipid profiles.
The Journal of Cell Biology, 2017 • August 7, 2017
Understanding how the transcription factor signal transducer and activator of transcription–3 (STAT3) controls glial scar formation may have important clinical implications. We show that astrocytic ST...
KEY FINDING: Astrocytic STAT3 is associated with greater amounts of secreted MMP2, a crucial protease in scar formation.
Arch Phys Med Rehabil, 2008 • April 1, 2008
This cross-sectional study examined the relationship between locomotive mode and C-reactive protein (CRP) levels in men with chronic spinal cord injury (SCI). The study found that CRP levels were inde...
KEY FINDING: Locomotive mode is independently related to circulating levels of CRP adjusting for BMI, a history of heart disease, and hypertension.
J Spinal Cord Med, 2008 • January 1, 2008
This study examined the association between the APOE e4 allele and outcomes after traumatic spinal cord injury (SCI). The study found that the APOE e4 allele was associated with worse motor recovery a...
KEY FINDING: Subjects with an APOE e4 allele had significantly less motor recovery during rehabilitation than did individuals without an e4 allele.
Tissue Eng Regen Med, 2023 • August 14, 2023
This study investigates the use of curcumin-loaded micelle nanoparticles (Cur-NPs) to enhance nerve regeneration and functional recovery after spinal cord injury (SCI) in rats by modulating the inflam...
KEY FINDING: Cur-NPs exhibit pH/temperature dual-sensitivity, enabling smart responsive release of curcumin in the inflammatory microenvironment after SCI, thus improving curcumin bioavailability.
Neurosci. Bull., 2022 • August 30, 2021
This study established a new mouse model of congenital hydrocephalus by deleting b-catenin in Nkx2.1-expressing ventral neural progenitors. The knockout mice consistently showed enlarged brains and ve...
KEY FINDING: Conditional knockout of b-catenin in Nkx2.1-expressing progenitors in mice leads to severe hydrocephalus from mid-gestation through adulthood, establishing a reliable animal model.
Eur J Appl Physiol, 2010 • April 3, 2010
This study compared oxidative stress levels between individuals with SCI and able-bodied subjects and assessed the impact of FES exercise on oxidative stress in SCI patients. The results showed no sig...
KEY FINDING: Baseline levels of oxidative stress and antioxidative capacity were similar between individuals with SCI and able-bodied subjects, suggesting a preserved (anti)oxidative status in SCI under basal conditions.
Cells, 2021 • August 28, 2021
This study investigates the unique loss of the central canal in the adult human spinal cord, comparing it to similar phenomena in Naked Mole-Rats (NMR) and hyh mice. The research highlights the distin...
KEY FINDING: Adult humans uniquely lose the central canal, which is replaced by a structure with large ependymal cell accumulations, astrogliosis, and perivascular pseudo-rosettes, unlike other mammals.
BMC Neuroscience, 2010 • July 22, 2010
This study investigated the effects of cyclic tensile stresses on cultured rat spinal cord cells using microarray analysis to identify changes in gene expression related to cell death. The results sho...
KEY FINDING: Cyclic tensile stress reduces the viability of cultured spinal cord cells in a dose- and time-dependent manner.