Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 121-130 of 620 results
Top Spinal Cord Inj Rehabil, 2023 • January 1, 2023
The study investigated risk factors and healthcare utilization costs associated with UTIs in individuals with SCI using IBM’s Marketscan Database from 2000-2019. Results showed that younger age, femal...
KEY FINDING: Younger age, female sex, thoracic level of injury, noncommercial insurance, and having at least one comorbidity were associated with increased odds of UTI.
Cell & Bioscience, 2023 • April 3, 2023
This study demonstrates that exosomes derived from vascular endothelial cells improve functional recovery and augment microglia/macrophages M2 polarization in vivo and in vitro. USP13 was highly upreg...
KEY FINDING: Exosomes derived from microvascular endothelial cells promote motor rehabilitation and M2 polarization of microglia/macrophages after SCI.
Open Forum Infectious Diseases, 2023 • February 16, 2023
This quasi-experimental study evaluated the efficacy of short antibiotic treatment durations (5-7 days) compared to longer durations (10 days) for osteomyelitis complicating pressure ulcers in spinal ...
KEY FINDING: A 5 to 7-day antibiotic treatment following surgical debridement and flap covering appears to be a safe and effective treatment strategy for osteomyelitis complicating pressure ulcers.
Turk J Phys Med Rehab, 2023 • December 23, 2022
This study aimed to investigate T-cell activity in patients with chronic SCI, determining the effects of autonomic dysfunction and the completeness of injury at different levels on cellular immune res...
KEY FINDING: Patients with incomplete SCIs had a higher skin response to candida compared to those with complete SCIs.
Frontiers in Immunology, 2024 • August 29, 2024
This review explores the use of spatial multi-omics technologies to understand the microenvironment after traumatic spinal cord injury (tSCI). The pathological mechanism of traumatic spinal cord injur...
KEY FINDING: Single-cell RNA sequencing (scRNA-seq) has advanced understanding of the pathophysiology of spinal cord injury, offering insights into new cell types/subtypes, neuroimmunology, biological states, and their activation.
Frontiers in Microbiology, 2022 • September 26, 2022
This study aimed to investigate the changes in lymphocyte subsets and gut microbiota in Chinese Han patients with SCI. It enrolled 23 SCI patients and 21 healthy controls, collecting blood and fecal s...
KEY FINDING: CD4 + cells, CD4 + /CD8 + ratio and CD4 + CD8 + cells in peripheral blood of SCI patients were significantly lower than those of the control group.
Spinal Cord Series and Cases, 2021 • February 5, 2021
This case report describes the diagnostic workup of fever of unknown origin in a 51-year-old male with multiple medical comorbidities who presented following an acute traumatic cervical spinal cord in...
KEY FINDING: The case highlights the importance of serial medical histories and physical examinations when investigating fever of unknown origin.
The Journal of Spinal Cord Medicine, 2020 • January 1, 2020
This retrospective cohort study examined the incidence and risk factors for healthcare facility-onset, healthcare facility-associated (HO-HCFA) Clostridioides difficile infection (CDI) in Veterans wit...
KEY FINDING: Antibiotic and PPI/H2 blocker use were independently associated with HO-HCFA CDI.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
The study aimed to develop quality indicators for urinary tract infection (UTI) management in spinal cord injury (SCI/D) rehabilitation to reduce inappropriate antibiotic use. A combination of evidenc...
KEY FINDING: A structure indicator was defined as the proportion of patients able to follow-up regarding urine culture results within 48-72 hours of collection.
Top Spinal Cord Inj Rehabil, 2019 • January 1, 2019
This clinical review addresses the unique challenges in the surveillance, prevention, diagnosis, and management of catheter-associated urinary tract infections (CAUTI) in individuals with spinal cord ...
KEY FINDING: Surveillance of CAUTI is challenging in the SCI population because the ability to detect symptoms typically used to diagnose CAUTI, such as suprapubic pain and dysuria, is often impaired.