Immunology Research

KEY FINDING: Enterovirus D68 is strongly linked to AFM outbreaks, supported by temporal and geographical correlations, its prevalence in AFM patients' samples, and recent strains showing increased neurovirulence in models.

KEY FINDING: Chronic SCI patients exhibit impaired circulating monocyte function, including diminished TLR4 expression, increased LPS-induced TNF-α production, and defective phagocytosis.

KEY FINDING: The incidence of UTI, as defined by NIDRR criteria, was 0% in the study population following urodynamic studies with fosfomycin prophylaxis.

KEY FINDING: Fecal microbiota transplantation (FMT) improved locomotor recovery in SCI mice, as indicated by increased BMS scores and improved gait parameters.

KEY FINDING: mtDNA abnormality triggers mitochondrial dysfunction, causing inflammatory responses and microglial activation and ultimately leading to irreversible neuronal death and loss of glial function.

KEY FINDING: SCI resulted in impaired sensorimotor functions, altered reflexes, and hypersensitivity to painful stimuli.

KEY FINDING: Older age at the time of SCI is associated with worse functional outcomes, even when injury severity, anatomical location, and injury type are controlled across age groups in rats and mice.

KEY FINDING: Significant improvement in MEP, PCF, functional capacity (1STST), and 6MWT between discharge (T1) and three months after discharge (T2).

KEY FINDING: A prolonged increase of activated ­CD8+ T cells occurs in the injured spinal cords, peaking at 14 days post-injury.

KEY FINDING: No association was observed between clinically actionable (A), bladder (B1), and urine quality (B2) symptoms and positive dipstick results.