Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 131-140 of 620 results
JOURNAL OF NEUROTRAUMA, 2020 • February 1, 2020
This study investigates the overexpression of TMEM176A and TMEM176B genes in circulating monocytes of individuals with chronic SCI, suggesting their potential role in suppressing dendritic cell functi...
KEY FINDING: TMEM176A and TMEM176B are significantly elevated in circulating monocytes from subjects with chronic SCI.
Clinical and Translational Medicine, 2021 • January 13, 2021
The study retrospectively analyzed data from 161 SCI patients admitted to Brisbane’s Princess Alexandra Hospital and validated findings with a cohort from the Trauma Hospital Berlin, Germany (n = 49)....
KEY FINDING: Acute neutrophilia in SCI patients is correlated with the New Injury Severity Score (NISS) but inversely correlated with neurological outcome (AIS grade).
Brain, Behavior, & Immunity - Health, 2020 • July 25, 2020
This study investigated the impact of nerve injury on mood disorders and memory loss, examining the roles of cytokines, growth factors, and glial cells in the process. The researchers induced nerve in...
KEY FINDING: Nerve injury induces depressive-like and anxiety-like behaviors as well as impairment in short-term memory in mice.
Spinal Cord, 2020 • February 18, 2020
This survey investigates the clinical algorithms relevant for SCI-AP and analyses the utility of the CDC-criteria for the diagnosis of SCI-AP and decision-making on its therapy. The accuracy in decisi...
KEY FINDING: Awareness of diagnostic CDC-criteria for pneumonia was confirmed by 88% of departments.
eLife, 2019 • December 3, 2019
This study establishes a murine model of sepsis with ICU-like interventions to investigate chronic muscle weakness in survivors. The research demonstrates that sepsis survivors have prolonged muscle w...
KEY FINDING: Sepsis survivors exhibit chronic muscle weakness for at least one month, even after muscle mass recovery.
Spinal Cord, 2020 • May 1, 2020
This study assessed the impact of multidrug-resistant gram-negative organisms (MDRGNOs) on outcomes in individuals with spinal cord injury/disorder (SCI/D). The results showed that having an MDRGNO cu...
KEY FINDING: MDRGNOs are prevalent in SCI/D, with 33.0% of the 8,681 individuals having a MDRGNO.
The Journal of Spinal Cord Medicine, 2017 • July 4, 2017
This study aimed to determine the association between pneumonia and pressure ulcers (PUs) in individuals with spinal cord injury (SCI) during acute care and rehabilitation. The study found a significa...
KEY FINDING: Individuals with pneumonia had a significantly higher presence of pressure ulcers compared to those without pneumonia in both acute care and inpatient rehabilitation settings.
Ann Rehabil Med, 2016 • August 26, 2016
This retrospective study investigated risk factors for urinary tract infection (UTI) following urodynamic study (UDS) in 140 spinal cord injury (SCI) patients receiving prophylactic antibiotics. The k...
KEY FINDING: A history of UTI within the past 4 weeks prior to the UDS was significantly associated with UTI occurrence after the UDS, even with prophylactic antibiotic therapy (p=0.006).
BMC Neurology, 2016 • August 26, 2016
This prospective study investigates the influence of SCI on NK cell activity, considering disease phases and lesion level dependency. The study hypothesizes that SCI impairs NK cell function, and this...
KEY FINDING: The primary endpoint of the study is CD107a expression by NK cells (cytotoxicity marker) 8–12 weeks following SCI.
Journal of Visualized Experiments, 2016 • September 12, 2016
The study presents a protocol to differentiate between immune system suppression and CNS protection for pharmacological interventions in autoimmune demyelination. It utilizes EAE models in mice, combi...
KEY FINDING: The protocol differentiates between treatments that suppress the immune system and those that directly protect the CNS during autoimmune demyelination.