Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 211-220 of 620 results
JOURNAL OF CLINICAL MICROBIOLOGY, 1997 • September 1, 1997
This study investigated the genetic diversity of Klebsiella pneumoniae isolates from patients with and without spinal cord injuries (SCI) to understand the recurrence of urinary tract infections (UTIs...
KEY FINDING: The RD6 genotype of K. pneumoniae was the most common cause of UTIs in SCI patients and was implicated in recurrent infections.
Eur Spine J, 1997 • January 1, 1997
This case report describes the successful management of a 65-year-old female patient with an extensive spinal epidural abscess (SEA) extending from C1 to T12, who presented with upper cervical cord co...
KEY FINDING: Emergency surgical decompression can be a life-saving procedure for extensive spinal epidural abscesses (SEAs) presenting with progressive neurological loss and multisystem failure.
J Physiol, 2013 • August 5, 2013
This study investigates the spatiotemporal dynamics of myelomonocytic cells following spinal cord injury (SCI) using intravital two-photon microscopy. The research identifies distinct recruitment prof...
KEY FINDING: Infiltrating LysM(+) cells are rapidly recruited to injury sites and are associated with the collapse of distended axon terminals (DATs) caudal of injury sites.
Dev Dyn, 2021 • June 1, 2021
Salamanders possess remarkable regenerative abilities, and the immune system plays a crucial role in these processes. Both innate and adaptive immune components are involved, with macrophages being pa...
KEY FINDING: Macrophages are recruited to the regenerating limb and heart, contributing to ECM remodeling, clearance of cellular debris and senescent cells.
Neural Regeneration Research, 2021 • September 1, 2021
Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Recent discoveries on the innate immune system ability to modulate stem cells f...
KEY FINDING: An acute and transient inflammation response is necessary to induce stem cell proliferation.
Experimental & Molecular Medicine, 2021 • April 15, 2021
The study investigates the role of 4-1BB signaling in age-related bone loss in mice. It finds that 4-1BB and its ligand 4-1BBL accumulate in the bone marrow of aged mice. Upregulation of 4-1BB in bone...
KEY FINDING: 4-1BB is upregulated in BMSCs from aged mice, which leads to the attenuation of osteogenic differentiation potential via the p38 MAPK-Dkk1 pathway.
AGING, 2021 • May 17, 2021
This study identified nine prognostic immune genes in extranodal diffuse large B-cell lymphoma (EN DLBCL) and established a multivariate predictive model based on these genes, demonstrating that patie...
KEY FINDING: Nine prognostic immune genes were identified in EN DLBCL, including IFNA21, KIR2DL1, MUCL1, SFTPA2, MX1, USP18, CCL1, IGLV1-36, and GLP1R.
Frontiers in Immunology, 2021 • May 10, 2021
The complement system plays crucial roles in CNS development, health, injury, and disease. This Research Topic gathers contributions on how complement factors interact with the nervous system, providi...
KEY FINDING: C3aR-/- mice have abnormalities in the organization and morphology of the adult neocortex, amygdala, and hippocampus, associated with motor hyperactivity and altered cognitive functions including short-term memory deficits.
Neural Regeneration Research, 2022 • January 1, 2022
Axonal regeneration after spinal cord injury is hindered by severe inflammation, the formation of a cavity of injury (COI) or arachnoiditis, and the presence of myelin. Inhibition of inflammation is a...
KEY FINDING: Severe inflammation following SCI, lasting over 16 weeks, is destructive to adjacent white matter.
J. Exp. Med, 2021 • August 2, 2021
This study used single-cell RNA sequencing to generate a detailed transcriptomic profile of cells at the spinal cord injury site. The researchers identified major cell types and their interactions dur...
KEY FINDING: The study identified distinct temporal regulation of angiogenesis, gliosis, and fibrosis by myeloid subtypes.