Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 221-230 of 620 results
Infection, 2021 • June 16, 2021
The study investigated the seroprevalence of anti-SARS-CoV-2 antibodies in Austrian blood donors, finding an overall rate of 2.5%. Younger donors showed higher seroprevalence, and rates increased over...
KEY FINDING: The overall anti-SARS-CoV-2 seroprevalence among Austrian blood donors was 2.5%.
Crit Care, 2021 • June 29, 2021
This study identifies CEA as a potential biomarker for COVID-19 patients, exploring its underlying mechanism through single-cell transcriptomics. The research reveals that developing neutrophils/neutr...
KEY FINDING: CEA was identified as the only laboratory indicator with a significant difference in both univariate and multivariate analyses.
J Neuroinflammation, 2021 • July 11, 2021
The study investigates the potential of Schwann cell-derived exosomes (SCDEs) to promote functional recovery after spinal cord injury (SCI) in mice. SCDEs treatment increases Toll-like receptor 2 (TLR...
KEY FINDING: SCDEs treatment promotes functional recovery and induces TLR2 expression on astrocytes while decreasing CSPGs deposition post-SCI.
Cell Death and Disease, 2021 • September 3, 2021
This study profiles transcriptomes and proteomes in a mouse model of AMI, revealing early immune system activation and pyroptosis. VX-765, a pyroptosis inhibitor, reduced infarct size and improved hea...
KEY FINDING: Immune system activation and subsequent pyroptosis occur in the early stages (6-24 hours) of AMI in a mouse model.
Journal of Neuroinflammation, 2021 • August 24, 2021
This study investigates the neuroprotective effects of tauroursodeoxycholic acid (TUDCA) in a mouse model of spinal cord injury (SCI). The results demonstrate that TUDCA treatment can alleviate second...
KEY FINDING: TUDCA reduces oxidative stress and protects cortical neurons in vitro, demonstrated by reduced ROS generation and LDH release.
The EMBO Journal, 2021 • September 29, 2021
This study investigates the role of DNA methylation in epidermal homeostasis by deleting Dnmt1 in mouse epidermis using Keratin 5-Cre (K5-Cre). The results show that DNMT1 ablation triggers a strong p...
KEY FINDING: Epidermis-specific deletion of DNMT1 disrupts epidermal structure and homeostasis, initiating a massive innate immune response and infiltration of immune cells.
Pharmacol Res Perspect, 2021 • May 1, 2021
Neurodegenerative diseases (NDD) are disorders characterized by the progressive loss of neurons affecting motor, sensory, and/or cognitive functions. Dr. Michal Schwartz originally conceived the conce...
KEY FINDING: Deregulation of immune homeostasis may represent one of the key initial steps in NDD.
Neurol Neuroimmunol Neuroinflamm, 2021 • November 1, 2021
The study demonstrates that teriflunomide (TF) enhances oligodendroglial differentiation in vitro at nanomolar concentrations, both on neonatal and adult purified OPCs in cultures, an effect mediated by a...
KEY FINDING: Teriflunomide (TF) promotes the differentiation of neonatal and adult mouse oligodendrocytes at nanomolar concentrations.
Science, 2021 • November 12, 2021
The immune system is implicated in the neurodegenerative process of Lewy body dementia. T cells home to the LBD brain and reside in close proximity to α-synuclein deposits. In conclusion, these result...
KEY FINDING: T cells are located in close proximity to Lewy bodies and dopaminergic neurons in the brains of individuals with LBD.
Cell Discovery, 2021 • January 1, 2021
This study comprehensively investigates pathophysiological and immunological changes in healthy volunteers after COVID-19 vaccination with an inactivated SARS-CoV-2 vaccine. The findings reveal consis...
KEY FINDING: Vaccination with an inactivated SARS-CoV-2 vaccine induces consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions.