Immunology Research
Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 381-390 of 730 results
Reversible myoclonus, asterixis, and tremor associated with high dose trimethoprim-sulfamethoxazole: a case report
The Journal of Spinal Cord Medicine, 2016 • January 1, 2016
A 66-year-old male with quadriplegia developed myoclonus, asterixis, and tremor after being treated with high-dose trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis jiroveci pneumonia (PJP). Sy...
KEY FINDING: High dose TMP-SMX can induce reversible myoclonus, asterixis, and tremor.
Cross-sectional associations of pulmonary function with systemic inflammation and oxidative stress in individuals with chronic spinal cord injury
The Journal of Spinal Cord Medicine, 2016 • May 1, 2016
This study examined the cross-sectional associations between systemic inflammation and oxidative stress with pulmonary function in individuals with chronic spinal cord injury (SCI). The objective was ...
KEY FINDING: Higher levels of systemic inflammation (CRP and IL-6) were associated with lower percent-predicted FEV1 and FVC measurements in individuals with chronic SCI. participants with higher levels of CRP and IL-6 had lower percent-predicted FEV1 and FVC measurements.
Anti-Inflammatory Effects of IL-27 in Zymosan-Induced Peritonitis: Inhibition of Neutrophil Recruitment Partially Explained by Impaired Mobilization from Bone Marrow and Reduced Chemokine Levels
PLOS ONE, 2015 • September 11, 2015
This study investigates the anti-inflammatory role of IL-27 in zymosan-induced peritonitis, focusing on its effects on neutrophil recruitment. The results demonstrate that IL-27 reduces neutrophil acc...
KEY FINDING: IL-27 treatment reduces neutrophil accumulation in the peritoneal cavity in a zymosan-induced peritonitis model.
Circulating T cell subsets are altered in individuals with chronic spinal cord injury
Immunol Res, 2015 • October 6, 2015
This study investigates the alterations in circulating T cell subsets in individuals with chronic spinal cord injury (SCI) compared to uninjured individuals, focusing on T cell and regulatory T cell (...
KEY FINDING: The frequency of CD3? and CD3? CD4? T cells are decreased in individuals with chronic SCI compared to uninjured individuals.
Role of glial 14-3-3 gamma protein in autoimmune demyelination
Journal of Neuroinflammation, 2015 • August 18, 2015
This study investigates the role of 14-3-3 γ in glial cells during autoimmune demyelination using a knockout mouse model of EAE. The findings indicate that 14-3-3 γ is expressed in oligodendrocytes an...
KEY FINDING: 14-3-3 γ mRNA expression increases in the spinal cord during the late chronic phase of MOG-EAE.
Prevalence of and Risk Factors for Multidrug-Resistant Bacteria in Urine Cultures of Spinal Cord Injury Patients
Ann Rehabil Med, 2015 • October 1, 2015
This retrospective study analyzed urine culture results from 2,629 spinal cord injury (SCI) patients admitted between 2001 and 2013 to determine the prevalence of multidrug-resistant (MDR) organisms a...
KEY FINDING: Significant bacteriuria was identified in 73.4% of urine samples from newly admitted SCI patients, and MDR organisms were isolated in 1.1% of cultures.
Spinal cord injury-induced immune deficiency syndrome enhances infection susceptibility dependent on lesion level
Brain, 2016 • January 10, 2016
This study investigates the link between spinal cord injury (SCI), a weakened immune system (SCI-IDS), and increased susceptibility to pneumonia, focusing on the impact of injury level on this relatio...
KEY FINDING: High thoracic spinal cord injuries in mice significantly increased bacterial load in the lungs, indicating increased susceptibility to pneumonia.
Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury
PLoS ONE, 2017 • January 25, 2017
This study investigates the role of PAR-1 in wound healing and locomotor recovery after spinal cord injury. The research demonstrates a detrimental role for thrombin-activated PAR-1 in the healing pro...
KEY FINDING: PAR-1 null mice showed reduced neutrophil infiltration and improved vascular integrity after spinal cord injury compared to wild-type mice.
Management of febrile urinary tract infection among spinal cord injured patients
BMC Infectious Diseases, 2016 • April 4, 2016
This retrospective study evaluated the impact of antibiotic treatment duration and monotherapy versus dual therapy on the cure rate of febrile UTIs in patients with neurogenic bladder. The study found...
KEY FINDING: There was no statistically significant difference in cure rates between the three antibiotic treatment duration groups (<10 days, 10-15 days, >15 days).
Risk factors for community-associated multidrug resistant Pseudomonas aeruginosa in Veterans with spinal cord injury and disorder: a retrospective cohort study
Spinal Cord, 2017 • July 1, 2017
This retrospective cohort study identified risk factors associated with community-associated multidrug resistant Pseudomonas aeruginosa (MDRPA) in Veterans with spinal cord injury and disorders (SCI/D...
KEY FINDING: Patients aged 50-64 years had a significantly higher risk of MDRPA compared to younger patients (18-49 years).