Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 421-430 of 620 results
Brain Pathology, 2012 • January 1, 2012
The study characterized the composition and distribution of spinal cord ECM during TMEV infection to identify underlying molecular mechanisms and transcriptional changes. Microarray analysis revealed ...
KEY FINDING: Progressive accumulation of chondroitin sulfate proteoglycans, glycoproteins, and collagens occurred within demyelinated TME lesions, paralleling astrogliosis development.
Brain, 2011 • September 1, 2011
This study investigates the distinct roles of soluble TNF and transmembrane TNF in experimental autoimmune encephalomyelitis (EAE) using pharmacological inhibitors. The researchers found that selectiv...
KEY FINDING: Selective inhibition of soluble TNF with XPro1595 improves the clinical outcome in experimental autoimmune encephalomyelitis (EAE).
Journal of Neuroinflammation, 2011 • November 13, 2011
This study examines the role of NG2, a proteoglycan expressed by OPCs, pericytes, and macrophages/microglia, in spinal cord demyelination and remyelination using wild type and NG2 null mice. Results s...
KEY FINDING: The initial volume of spinal cord demyelination in wild type mice is twice as large as in NG2 null mice, suggesting NG2 influences the initial damage phase.
PLoS ONE, 2011 • November 11, 2011
This study investigates the roles of Nogo receptors NgR1 and NgR2 in the regulation of CD4 T helper responses and CNS repair during experimental autoimmune encephalomyelitis (EAE). The researchers fou...
KEY FINDING: Genetic deletion of NgR1 and NgR2 does not promote functional recovery during EAE.
Cell. Mol. Life Sci., 2012 • May 1, 2012
This study characterizes the morphology and function of leech blood cells, highlighting their involvement in both peripheral immunity and CNS neural repair. The research demonstrates the presence of a...
KEY FINDING: Leeches possess a unique type of blood cell that participates in various immune processes, including antibacterial and antiparasitic defense mechanisms.
PLoS ONE, 2011 • December 21, 2011
This study demonstrates that the glial scar matrix serves as a necessary scaffold, skewing monocytes towards the resolving phenotype, characterized by the production of the anti-inflammatory cytokine ...
KEY FINDING: The glial scar matrix CSPG skews infiltrating monocytes towards a resolving, anti-inflammatory phenotype.
Journal of Neuroinflammation, 2012 • March 15, 2012
This study investigates the role of ADAMTS-4, a proteoglycan-degrading enzyme, in promoting functional recovery after spinal cord injury (SCI). The research demonstrates that ADAMTS-4 can degrade CSPG...
KEY FINDING: ADAMTS-4 degrades endogenous CSPGs like brevican, neurocan, and phosphacan, reversing their inhibition of neurite outgrowth in vitro.
Journal of Neuroinflammation, 2012 • May 7, 2012
This study investigates the role of IFNγ in synaptic plasticity and nerve regeneration following peripheral nerve injury in mice. The researchers compared wild-type mice with IFNγ−/− mutant mice after...
KEY FINDING: IFNγ−/− mutant mice showed decreased expression of MHC I and β2-microglobulin mRNA in the lesioned spinal cord segment.
Brain and Behavior, 2012 • January 3, 2012
This study examined Gpnmb expression in the CNS of adult rats under normal and inflammatory conditions, finding Gpnmb mRNA expression in several brain regions and the spinal cord. Immunohistochemical ...
KEY FINDING: Gpnmb mRNA is expressed in the cerebrum, cerebellum, brain stem, and spinal cord of normal adult rats.
PLoS ONE, 2012 • May 22, 2012
This study investigated the gene expression differences between wild-type and EphA4 knockout mice following spinal cord injury to understand the mechanisms underlying functional recovery. Microarray a...
KEY FINDING: EphA4 knockout mice show altered expression of genes related to inflammation following spinal cord injury, specifically an attenuated expression of inflammatory genes.