Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 431-440 of 620 results
Stem Cells, 2012 • November 1, 2012
This study demonstrates that allogeneic NPCs are rejected following transplantation into the inflamed CNS of JHMV-infected mice due to T cell-mediated immune responses. The research highlights that al...
KEY FINDING: Allogeneic NPCs are antigenic and induce a delayed-type hypersensitivity (DTH) response, indicating T cell involvement.
Journal of Neuroinflammation, 2013 • January 14, 2013
This study challenges previous in vitro findings by demonstrating that IL-1β exerts detrimental effects on axon plasticity, lesion development, and gliosis after spinal cord injury (SCI) in mice. The ...
KEY FINDING: Local application of recombinant IL-1β worsened the neurological outcome after SCI in mice.
EMBO Mol Med, 2013 • June 1, 2013
This study demonstrates that etifoxine, a clinically available TSPO ligand, exhibits neuroprotective and anti-inflammatory effects in a mouse model of multiple sclerosis (EAE). Etifoxine administratio...
KEY FINDING: Etifoxine attenuated EAE severity when administered before the development of clinical signs and improved symptomatic recovery when administered at the peak of the disease.
Clinical and Experimental Immunology, 2013 • January 1, 2013
This study investigates the neuroprotective effects of C5a after spinal cord injury (SCI). It examines the impact of C5a administration at different time points relative to the injury, both in vivo an...
KEY FINDING: Delayed administration of C5a (24 hours post-injury) significantly improved locomotor function in mice after SCI.
Clinical and Developmental Immunology, 2013 • July 2, 2013
This study compared the astrogliosis and macrophage/microglial cell responses 7 days after either immunological demyelination or a stab injury to the dorsal funiculus of rats. It also examined the ast...
KEY FINDING: Immunological demyelination induces a robust macrophage/microglial cell activation.
Brain Behav Immun, 2014 • March 1, 2014
This study reports that adrenomedullin provides a highly effective therapy for chronic EAE by reducing inflammatory infiltrates in the CNS and subsequent demyelination and axonal damage. Adrenomedulli...
KEY FINDING: Adrenomedullin treatment reduced the clinical severity and incidence of EAE, the appearance of inflammatory infiltrates in spinal cord and the subsequent demyelination and axonal damage.
Immunology, 2014 • February 1, 2014
Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous system (CNS), is the major cause of cognitive and motor dysfunction. The growing awareness that the immune sys...
KEY FINDING: Chronic activation of innate immune responses, especially by microglia, is a common link among various neurodegenerative diseases, potentially leading to neurotoxic pathways and progressive degeneration.
Journal of Neuroinflammation, 2014 • April 5, 2014
This study investigated the effect of the specific EGFR inhibitor PD168393 on reactive astrogliosis and proinflammatory cytokine secretion of reactive astrocytes in a scratch injury in vitro model and...
KEY FINDING: EGFR phosphorylation parallels astrocyte activation, and the EGFR inhibitor PD168393 effectively inhibited scratch-induced reactive astrogliosis and proinflammatory cytokine/mediator secretion of reactive astrocytes in vitro.
Neuroscience, 2014 • December 26, 2014
Acute brain injuries cause rapid cell death that activates bidirectional crosstalks between the injured brain and the immune system. Here we have reviewed the available information about the role and ...
KEY FINDING: Early immune activation after acute CNS injury might have neuroprotective effects.
Neural Regen Res, 2013 • December 1, 2013
This study investigates the role of PD-L1 in the pathogenesis of experimental allergic encephalomyelitis (EAE), a mouse model for multiple sclerosis (MS). The researchers induced EAE in C57BL/6J mice ...
KEY FINDING: PD-L1 expression was significantly increased in the spinal cord of EAE mice compared to control mice, as shown by immunohistochemical staining.