Immunology Research

KEY FINDING: Pregabalin treatment delayed the onset of EAE, as evidenced by statistical differences at days 10 and 16 after immunization.

KEY FINDING: Microglia/macrophages exhibit a dynamic shift in phenotype after CNS injury, with an initial M2-dominant phase followed by a later M1-dominant phase.

KEY FINDING: Gal1 mRNA and protein expression are significantly increased in the lesion epicenter during the first week post-SCI.

KEY FINDING: Quercetin, a key ingredient in Jisuikang (JSK), protects microglial cells from LPS-induced inhibition of cell viability and cellular inflammation.

KEY FINDING: The size of NPs affects how they are taken up by cells, influencing the immune response. Smaller NPs tend to be internalized through different pathways than larger NPs.

KEY FINDING: Spatiotemporal dynamic neuroinflammation plays an important role in secondary injury after SCI. Inflammatory cells and mediators have different roles at different stages of inflammation.

KEY FINDING: Most studies used inbred, young adult, male mice with peripheral nerve injury, limiting the generalizability of the data.

KEY FINDING: EJCDs promote HSC self-renewal and erythroid differentiation in the bone marrow by upregulating FZD4 protein expression in LSK cells.

KEY FINDING: The combination of ceftriaxone and ADMSCs resulted in significantly lower levels of TNF-α and IL-6 in both circulatory and spinal cord fluid compared to ceftriaxone or ADMSCs alone, indicating a stronger anti-inflammatory effect.

KEY FINDING: SIX1 expression increases in microglia following SCI in mice and is positively correlated with the M1 microglia marker iNOS and negatively correlated with the M2 microglia marker Arg1.