Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 521-530 of 620 results
Frontiers in Immunology, 2021 • July 9, 2021
This study demonstrates that EV71 infection in mice leads to significant muscle tissue damage, including myositis and calcification, which contributes to limb paralysis. The research highlights the im...
KEY FINDING: EV71 infection induces severe myositis and muscle calcification in mice, contributing to limb paralysis. The muscle damage peaks at 5-7 days post-infection, followed by gradual recovery.
Dev Cell, 2024 • February 26, 2024
The study dissects macrophage phenotypes in spiny mice (Acomys spp.) that regenerate ear pinnae tissue versus lab mice (Mus musculus) that form scar tissue, identifying secreted factors from activated...
KEY FINDING: Acomys macrophages exhibit a muted inflammatory profile compared to Mus macrophages and secrete factors that antagonize collagen production and drive matrix remodeling.
Translational Psychiatry, 2020 • July 15, 2020
The study investigated neuroinflammatory alterations in high trait anxiety using a mouse model (HAB). Results showed increased microglial density and activity in the hippocampus of HAB mice, particula...
KEY FINDING: HAB mice exhibited enhanced density and average cell area of Iba1+ microglia in the dentate gyrus (DG) of the hippocampus compared to NAB controls.
Neurobiol Dis, 2022 • February 1, 2022
This study investigates the contribution of myelin to foamy macrophage formation after spinal cord injury (SCI). The researchers found that foamy macrophages can still form without myelin, both in vit...
KEY FINDING: Foamy macrophages can form without myelin both in vitro and in vivo, suggesting that non-myelin debris contributes to foamy macrophage formation after SCI.
Clin Exp Immunol, 2021 • September 7, 2021
This review explores the proregenerative roles of Tregs in zebrafish and mammals, highlighting the FoxP3-dependent immunosuppressive function of Tregs in zebrafish as a useful model for future researc...
KEY FINDING: Zebrafish possess two FOXP3 orthologs, foxp3a and foxp3b, potentially serving a redundant role in Treg formation and activity.
Journal of Inflammation Research, 2016 • September 22, 2016
This study aimed to determine if BMP-7 contributes to improved bone regeneration in nonunion therapy by modulation of angiogenic and inflammatory cytokine expression patterns. The study found that BMP...
KEY FINDING: BMP-7 increases VEGF levels, which promote angiogenesis, essential for bone healing.
Journal of Orthopaedic Surgery and Research, 2018 • December 4, 2018
This study evaluated the efficacy of a modified vacuum-assisted closure (VAC) for treating early postoperative spinal wound infections. The results show that the size of the wound after treatment with...
KEY FINDING: Wound size significantly decreased after 1 week of modified VAC treatment.
International Journal of Molecular Sciences, 2021 • July 30, 2021
This study demonstrates that distinct preceding induction by activin A, BMP-4, CHIR, and VEGF in lipid-enriched APEL medium resulted in a significant increase of hiPSC-derived platelet production using...
KEY FINDING: A modified protocol including activin A and CHIR99021 significantly increased HEC differentiation, resulting in improved MK production.
Journal of Leukocyte Biology, 2023 • August 9, 2023
Numerous studies have demonstrated that macrophages can proliferate during homeostasis and in response to infection, injury, and disease. Macrophages proliferate in various organs and tissues, includi...
KEY FINDING: Macrophages proliferate in various organs and tissues, including skin, peritoneum, lung, heart, aorta, kidney, liver, pancreas, brain, spinal cord, eye, adipose tissue, and uterus, and in different species including mouse, rat, rabbit, and human.
Journal of Cellular Physiology, 2022 • March 1, 2022
The study investigates the effect of inflammatory stimuli and bile acids on myelin clearance by macrophages. Activation of the LPS-TLR4/NFκB pathway reduces myelin phagocytosis by bone marrow-derived ...
KEY FINDING: Activation of the TLR4-NFκB pathway reduced myelin uptake by bone marrow-derived macrophages (BMDM), while IFNγ-Jak/STAT1 signaling did not.