Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 531-540 of 620 results
Glia, 2022 • October 1, 2022
This study demonstrates the capacity of digoxin to induce OPC differentiation in vitro, to robustly stimulate myelination in vivo in the chemically-induced cuprizone and lysophosphatidylcholine (LPC) ...
KEY FINDING: Digoxin regulated multiple genes in oligodendrocyte progenitor cells (OPCs) essential for oligodendrocyte (OL) differentiation in vitro, promoted OL differentiation both in vitro and in vivo in female naïve C57BL/6J (B6) mice, and stimulated recovery of myelinated axons in B6 mice following demyelination in the corpus callosum induced by cuprizone and spinal cord demyelination induced by lysophosphatidylcholine (LPC), respectively.
Ann Rehabil Med, 2015 • October 1, 2015
This retrospective study analyzed urine culture results from 2,629 spinal cord injury (SCI) patients admitted between 2001 and 2013 to determine the prevalence of multidrug-resistant (MDR) organisms a...
KEY FINDING: Significant bacteriuria was identified in 73.4% of urine samples from newly admitted SCI patients, and MDR organisms were isolated in 1.1% of cultures.
Journal of Neuroinflammation, 2025 • January 28, 2025
This study identifies heterogeneous nuclear ribonucleoprotein U (Hnrnpu) as a potential endogenous molecule that regulates astrocyte proliferation and the following scar formation. Inhibition of Hnrnp...
KEY FINDING: Hnrnpu promotes astrocyte reactivity. Inhibiting Hnrnpu suppresses astrocyte migration and alters expression of the genes associated with astrocyte reactivity in vitro.
Gene Regulation and Systems Biology, 2007 • January 1, 2007
This study investigates the role of fetal cells in maternal body injuries, demonstrating that injury dramatically increases the amount of fetal cells in the maternal body. Injury promotes fetal cell m...
KEY FINDING: Skin injuries during pregnancy increased microchimerism of GFP expressing cells from the GFP transgenic progenies.
Neural Regen Res, 2018 • April 1, 2018
This study investigated the effects of combining macrophage depletion with Schwann cell transplantation in a rat model of contusive spinal cord injury. The rationale was to reduce inflammation and imp...
KEY FINDING: The combined treatment of macrophage depletion and Schwann cell transplantation significantly reduced cyst volumes in the injured spinal cord compared to Schwann cell transplantation alone.
Immunol Res, 2015 • October 6, 2015
This study investigates the alterations in circulating T cell subsets in individuals with chronic spinal cord injury (SCI) compared to uninjured individuals, focusing on T cell and regulatory T cell (...
KEY FINDING: The frequency of CD3? and CD3? CD4? T cells are decreased in individuals with chronic SCI compared to uninjured individuals.
Journal of Inflammation Research, 2025 • February 20, 2025
In the present study, we statistically analyzed the DEGs between SCI and normal tissue in the GSE5296 and GSE47681 datasets to obtain DEGs. The exploration of the relevance of differential genetic, bi...
KEY FINDING: A total of 522 DEGs were filtered. Enrichment analysis of their biological functions and pathways yielded the most closely related results for inflammatory response, regulation of cytokine production, neutrophil chemotaxis and degranulation, angiogenesis, cell death, TNF signaling pathway, and osteoclast differentiation.
J Immunother Cancer, 2021 • January 1, 2021
This study demonstrates the feasibility of redirecting pre-existing viral immunity against measles virus (MeV) to inhibit tumor growth in a preclinical model of aggressive squamous cell carcinoma. The...
KEY FINDING: MeV vaccination generated cytotoxic T lymphocyte (CTL) immunity in mice, demonstrated by enhanced interferon gamma production and antigen-specific T cell proliferation.
Journal of Cerebral Blood Flow & Metabolism, 2012 • May 2, 2012
This review discusses the principles of neuroinflammation, focusing on the role of microglia and common neurologic disease mechanisms. It also highlights the molecular targets currently used and explo...
KEY FINDING: Microglial activation, a key component of neuroinflammation, can be imaged using TSPO-targeting tracers in various neurological diseases.
Medicine, 2014 • December 1, 2014
This study analyzed a large claims database to compare the effectiveness of different oral antibiotics for urinary tract infections (UTIs) in outpatients. The results suggest that norfloxacin and oflo...
KEY FINDING: Norfloxacin had the lowest treatment failure rate compared to TMP-SMX in crude estimate (OR, 0.73; 95% CI, 0.57–0.94), individual covariate adjustment (OR, 0.70; 95% CI, 0.54–0.90), and propensity score matched analysis (OR, 0.73; 95% CI, 0.54–1.00).