Immunology Research

KEY FINDING: UniTCR enables detailed single-modality analysis by incorporating information from the other modality, offering a detailed understanding beyond what conventional single-modality approaches provide.

KEY FINDING: Ectopic expression of allogeneic MHC in the recipient thymus leads to stable expression in TECs and DCs.

KEY FINDING: The study highlights a rare case of cervical spine pyogenic infection (CSPI) stemming from chronic paronychia, emphasizing that infections can originate from unexpected sources.

KEY FINDING: Seven signature genes (ARG1, RETN, BPI, GGH, CCNB1, HIST1H2AC, and HIST1H2BJ) were identified as potential biomarkers for early SCI diagnosis.

KEY FINDING: hMSCs are well tolerated in the murine model of acute asthma, suggesting that hMSCs can favorably change the outcome of asthmatic inflammation without the pathology associated with cross-species application.

KEY FINDING: S100A4 is upregulated in fibroblasts from ALS patients, regardless of the specific gene mutation, suggesting it is a common pathological trait.

KEY FINDING: NETs are key mediators of inflammation and thrombosis, and have been widely accepted as a mechanism of deep vein thrombosis.

KEY FINDING: PfAP2-G5 suppresses the transcriptional activity of the pfap2-g gene via binding to both the upstream region and exonic gene body, preventing initiation of sexual commitment.

KEY FINDING: Stem cells can differentiate into neural cells and produce growth factors that promote neuronal survival and axonal regrowth in the SCI microenvironment.

KEY FINDING: Foam cells (foamy macrophages) accumulate in the invasive fibrotic meninges during gap regeneration of transected adult Axolotl spinal cord and may act beneficially.