Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 551-560 of 620 results
Frontiers in Microbiology, 2021 • January 8, 2021
The study optimized the CRISPR/Cas system for genome editing in Plasmodium falciparum by developing an integrating strategy (Cas9i) and adapting the CRISPR/Cpf1 system. The Cas9i system significantly ...
KEY FINDING: The Cas9i system significantly shortened the time required to generate transgenic strains of P. falciparum.
J Clin Apher, 2020 • February 1, 2020
This study evaluated the efficacy and safety of IgE-selective immunoadsorption (IA) in treating severe atopic dermatitis (AD). Five patients with severe AD underwent three courses of IA, which resulte...
KEY FINDING: IgE-selective IA effectively reduced serum IgE levels in all participants by an average of 81% per cycle.
Prog Neurobiol, 2023 • September 1, 2023
Neutrophils, once viewed as simple pathogen-clearing cells, are now recognized as heterogeneous and dynamic immune cells with diverse functions in the nervous system. Their involvement spans from caus...
KEY FINDING: Neutrophils are involved in both detrimental and beneficial processes in the CNS and PNS, impacting conditions such as stroke, Alzheimer's disease, multiple sclerosis, and spinal cord injury.
Glia, 2011 • December 1, 2011
This study investigates the role of CXCR4 signaling in regulating remyelination by endogenous oligodendrocyte progenitor cells (OPCs) in a viral model of demyelination. The findings suggest that CXCR4...
KEY FINDING: CXCR4 signaling is required for OPCs to mature and contribute to remyelination in response to JHMV-induced demyelination.
Neurobiol Dis., 2015 • February 1, 2015
This study investigates the role of macrophages in fibrotic scar formation after spinal cord injury (SCI). The research demonstrates that hematogenous macrophages (hMΦ), not microglia, are primarily a...
KEY FINDING: Hematogenous macrophages, rather than microglia, are predominantly present in the fibrotic scar after spinal cord injury.
Frontiers in Cellular and Infection Microbiology, 2023 • May 5, 2023
This study investigates the pathogenic mechanisms of Prototheca wickerhamii by integrating transcriptomics, proteomics, and metabolomics data from different strains. The researchers identified that do...
KEY FINDING: Mannan endo-1,4-b-mannosidase was significantly downregulated in the mucous strain (S1) of P. wickerhamii, contributing to a thinner cell wall.
BMC Infectious Diseases, 2023 • November 14, 2023
This study aimed to determine the rate of post-COVID-19 syndrome (PCS) among SARS-CoV-2 seropositive blood donors and to investigate the role of Epstein-Barr virus (EBV) reactivation in PCS. The resul...
KEY FINDING: 18% of individuals with asymptomatic or mild SARS-CoV-2 infections experienced PCS symptoms lasting up to one year.
The Journal of Neuroscience, 2013 • August 7, 2013
This study investigates the role of MMP-9 in remote inflammation and motor relearning after spinal cord injury (SCI) in mice. The findings demonstrate that elevated MMP-9 in the lumbar cord early afte...
KEY FINDING: MMP-9 is upregulated in the lumbar enlargement after thoracic SCI, resulting in remote inflammation during the first week after injury in C57BL/6 mice.
Journal of Neuroinflammation, 2021 • January 12, 2021
This study demonstrates that microglial inflammation after spinal cord injury is enhanced by reactive astrocytes through the fibronectin/β1 integrin pathway. Administration of β1Ab can ameliorate both...
KEY FINDING: β1Ab treatment altered microglial distribution within the glial scar after SCI, promoting a more even distribution instead of concentration in the lesion core.
Frontiers in Immunology, 2023 • September 8, 2023
This study comprehensively analyzed gene expression in patients with PSID after major abdominal surgery to identify hub genes associated with immune and metabolic alterations. The analysis revealed si...
KEY FINDING: Identified 512 upregulated and 254 downregulated DEGs in patients with PSID compared with controls, significantly associated with immune- and metabolism-related biological processes and pathways.