Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 541-550 of 620 results
Disease Markers, 2022 • May 11, 2022
The study investigates the role of DYNC1H1 in LIHC using bioinformatics and experimental analysis, finding that DYNC1H1 expression is associated with clinicopathological features and poor prognosis. G...
KEY FINDING: DYNC1H1 expression levels were associated with T classification, pathologic stage, histologic grade, and serum AFP levels in LIHC patients.
Acta Neuropathologica Communications, 2020 • January 1, 2020
The study investigates the role of microglia in leukotriene (LT) biosynthesis in the context of Alzheimer's Disease (AD). It identifies the key enzyme 5-Lipoxygenase (5-Lox) primarily in neurons and t...
KEY FINDING: FLAP, a key activator of the LT pathway, is found in all microglia and no other brain cells.
Cell Death & Differentiation, 2019 • April 5, 2019
The study examined the impact of Zika virus (ZIKV) on human neural progenitor cells (NPCs) derived from different brain regions, finding that ZIKV infects these cells similarly, leading to growth arre...
KEY FINDING: ZIKV efficiently infects human NPCs from various brain regions (forebrain dorsal, forebrain ventral, hindbrain, and spinal cord) derived from human embryonic stem cells.
JOURNAL OF NEUROTRAUMA, 2018 • November 1, 2018
The study investigated the relationship between plasma GFAPab, CRMP2ab, and neuropathic pain in SCI patients. The presence of plasma GFAPab in the chronic stage of injury does not differentiate betwee...
KEY FINDING: Plasma GFAPab in the chronic stage of SCI does not correlate with neuropathic pain.
AGING, 2020 • November 24, 2020
This study investigates the non-autophagic role of Atg7 on hematopoietic cells, finding that its loss reduces CD11b myeloid cellularity in mouse bone marrow. Specifically, Atg7 deletion results in the...
KEY FINDING: Atg7 deletion in the hematopoietic system reduces CD11b myeloid cellularity in mouse bone marrow, specifically affecting CD11b+Ly6G+ and CD11b+Ly6G- populations.
Scientific Reports, 2019 • March 7, 2019
This study investigates the role of mouse mast cell protease 4 (mMCP4) in scar development after spinal cord injury (SCI). The absence of mMCP4 in knockout mice results in exacerbated scar formation a...
KEY FINDING: mMCP4−/− mice showed decreased locomotor performance and increased scar formation at the lesion site after SCI.
Chinese Journal of Reparative and Reconstructive Surgery, 2022 • October 1, 2022
This study aimed to develop an anti-inflammatory PLGA scaffold by loading xanthohumol to promote cartilage regeneration. The results showed that the xanthohumol-loaded scaffolds had suitable pore size...
KEY FINDING: The xanthohumol-loaded PLGA scaffolds exhibited anti-inflammatory properties in vitro, reducing the expression of inflammatory cytokines (IL-1β and TNF-α) in macrophages.
Journal of Neuroinflammation, 2012 • February 27, 2012
This study investigated the effects of temporal IL-6 signaling blockade on macrophage activation and inflammation following spinal cord injury (SCI) in mice. The results showed that MR16-1 treatment p...
KEY FINDING: MR16-1 treatment increased the area of spared myelin and promoted nerve fiber regeneration after spinal cord injury.
Cell Communication and Signaling, 2024 • August 6, 2024
This study confirms a myeloproliferative role of NLRP3 by demonstrating that the expression of NLRP3 and the NLRP3 inflammasome-related genes ASC, IL1B, and IL18 is increased in AML patient cells comp...
KEY FINDING: Elevated NLRP3 expression is associated with diminished overall survival in AML patients, suggesting a critical role in AML pathogenesis.
International Journal of Medical Sciences, 2022 • November 14, 2022
This review summarizes the role of CXCL10 in spinal cord injury (SCI), highlighting its involvement in acute inflammatory responses, secondary damages, and complications. CXCL10, a chemokine, is upreg...
KEY FINDING: CXCL10, a chemokine, is significantly upregulated following SCI and plays a crucial role in the development of neuroinflammation.