Browse the latest research summaries in the field of immunology for spinal cord injury patients and caregivers.
Showing 561-570 of 620 results
Neurobiol Dis., 2016 • September 1, 2016
The study demonstrates that the thrombin receptor (PAR1) is a critical regulator of inflammation and astrogliosis after traumatic SCI. Targeting PAR1 genetically improved neurobehavioral outcomes, red...
KEY FINDING: PAR1 knockout mice displayed improved locomotor recovery after SCI and reduced signatures of inflammation and astrogliosis.
Biomaterials, 2014 • September 1, 2014
The study investigates the distinct roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted intracortical microelectrodes using a bone marrow chimera m...
KEY FINDING: There was no correlation between microglia populations and neuron populations at the microelectrode-tissue interface.
Biol Blood Marrow Transplant, 2018 • July 1, 2018
The study highlights significant variability in MSC manufacturing protocols across European centers, impacting the consistency of clinical products. Key variations were identified in tissue sources, c...
KEY FINDING: Most centers use bone marrow as the source for MSCs, but there's a shift from fetal bovine serum to human platelet lysate as a medium supplement.
Frontiers in Cellular Neuroscience, 2016 • February 9, 2016
This study challenges the dogma that the CNS is an alymphatic environment by investigating the expression of lymphatic markers LYVE-1 and PROX1 in the adult rat spinal cord. The research identified nu...
KEY FINDING: PROX1-immunoreactivity was detected in numerous nuclei evenly distributed throughout the gray and white matter of the rat adult spinal cord.
Frontiers in Immunology, 2024 • July 4, 2024
This study demonstrates that MVP is markedly increased in PAAD tissues and correlated with an adverse prognosis. Related analyses confirmed its potential as a novel diagnostic and prognostic indicator...
KEY FINDING: MVP is abnormally upregulated in PAAD tissues and correlates with adverse prognosis.
Neural Regeneration Research, 2023 • August 1, 2023
This study demonstrates the positive effects of inhibiting tau expression in the treatment of SCI, showing improved nerve tissue repair and functional recovery. Tau inhibition reduces inflammation, al...
KEY FINDING: Tau inhibition after spinal cord injury down-regulated the levels of inflammatory mediators, including tumor necrosis factor-α, interleukin-6 and interleukin-1β.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study evaluated the impact of long-term nitrofurantoin for UTI prophylaxis in veterans with SCI. Long-term prescription of nitrofurantoin may reduce UTIs in veterans with SCI and there is no evid...
KEY FINDING: UTIs were less frequent in cases receiving long-term nitrofurantoin compared to controls.
Mediators of Inflammation, 2017 • May 10, 2017
This study investigates the effects of methylprednisolone (MP) on edema and aquaporin 4 (AQP4) expression in rats following spinal cord injury (SCI). The results indicate that MP, contrary to its inte...
KEY FINDING: SCI increased AQP4 expression in the spinal cord white matter, and MP diminished this increase to baseline levels.
Journal of Orthopaedic Surgery and Research, 2017 • March 24, 2017
This study investigates the roles of iron overload and subsequent microglia activation in the remodeling of the brain after SCI. The results indicate that after SCI, activation of IRP can lead to intr...
KEY FINDING: SCI induces intracranial iron overload, especially in the hindlimb sensory area, hippocampus, and thalamus.
PLoS ONE, 2012 • August 13, 2012
This study investigates the potential neuroprotective effects of G-CSF on synaptic elements related to spinal alpha-motoneurons following sciatic nerve axotomy in MDX mice, an animal model for Duchenn...
KEY FINDING: G-CSF treatment led to a greater preservation of synaptic inputs after injury in MDX mice compared with untreated and placebo groups.