Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 61-70 of 269 results
The Journal of Spinal Cord Medicine, 2023 • March 1, 2023
This retrospective study examined pathological fractures in Veterans with Spinal Cord Injury or Disorder (SCID) using administrative data from 2005-2015. The objective was to determine how often lower...
KEY FINDING: Approximately 2% of lower extremity fractures in Veterans with SCID were coded as pathological fractures.
Exp Physiol, 2022 • August 1, 2022
The investigation examined changes in the gene and protein expression of Notch, Numb, and Numb-like (Numbl) in human skeletal muscle after an acute bout of eccentric exercise-induced muscle damage. Th...
KEY FINDING: Notch1 mRNA expression trended toward a significant increase from Pre to 2 Days post-muscle damage from baseline measures (p = 0.087).
Spinal Cord Series and Cases, 2022 • May 6, 2022
The study investigated the impact of FES-assisted dynamic load-shifting exercises on bone mineral density (BMD) in individuals with complete spinal cord injury (SCI). The results indicated improvement...
KEY FINDING: Participants with acute and subacute SCI showed an absolute increase of trabecular vBMD (vBMDTRAB) in the proximal (mean of 26.9%) and distal tibia (mean of 22.35%).
Healthcare, 2022 • May 25, 2022
This prospective study investigated sclerostin levels and bone biomarker trends in patients with spinal cord injury (SCI). The study aimed to determine the serum concentration of sclerostin and factor...
KEY FINDING: Sclerostin levels significantly correlated with age, CTX level, and hip BMD in patients with SCI.
J. Clin. Med., 2022 • June 29, 2022
The study investigated the reproducibility and accuracy of REMS for femoral BMD estimation and the discriminative power of the REMS-derived femoral fragility score in patients with primary and disuse-...
KEY FINDING: REMS demonstrated excellent test-retest reproducibility for estimating femoral neck BMD, total femur BMD, and the femoral fragility score in both patient groups.
Frontiers in Endocrinology, 2022 • August 5, 2022
This study evaluated the differential expression of miRNAs in subjects with chronic SCI, acute SCI, and no SCI to investigate the association of these miRNAs with SCI mediated osteoporosis and related...
KEY FINDING: MiR-148a-3p was upregulated in subjects with acute SCI vs chronic SCI, as well as in acute SCI vs no SCI.
Top Spinal Cord Inj Rehabil, 2022 • July 1, 2022
The study compared the incidence of musculoskeletal (MSK) morbidities in adults with and without cerebral palsy (CP) or spina bifida (SB) using a large insurance claims database. Results showed that a...
KEY FINDING: Adults with CP or SB had a significantly higher incidence of any MSK morbidity (55.3% vs. 39.0%) compared to controls.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This scoping review examined the literature regarding methodologies to assess fracture risk, prevent and treat osteoporosis, and manage osteoporotic fractures in SCI/D patients. The review found that ...
KEY FINDING: Risk of osteoporotic fractures in SCI is predicted by a combination of DXA-defined low BMD plus clinical and demographic characteristics.
Physiological Reports, 2019 • October 1, 2019
This study compared the effects of abaloparatide and teriparatide on bone structure, turnover, and signaling pathways in mice and cells. The results showed that abaloparatide had a greater osteoanabol...
KEY FINDING: Abaloparatide caused a greater dose-dependent increase in cortical thickness than teriparatide.
Spinal Cord, 2020 • March 1, 2020
This study demonstrates that rapid bone loss occurs as early as 2 days after a complete spinal cord injury (SCI) in rats. The researchers found a decrease in bone mass and deterioration of bone micros...
KEY FINDING: Neurologically motor-complete SCI causes loss of bone mass and deterioration of trabecular bone microstructure as early as 2 days after injury.