Browse the latest research summaries in the field of musculoskeletal medicine for spinal cord injury patients and caregivers.
Showing 51-60 of 269 results
Top Spinal Cord Inj Rehabil, 2021 • July 1, 2021
The study established predictive equations for peak torque of muscle groups with totally and partially preserved innervation in individuals with motor complete SCI. Handgrip strength was found to be a...
KEY FINDING: Handgrip strength was a significant predictor of shoulder abduction and adduction peak torque.
Top Spinal Cord Inj Rehabil, 2021 • September 1, 2021
This study determined optimal handgrip strength (HGS) cutoff points for greater functional independence and wheelchair skills in men with spinal cord injury (SCI). The HGS was a significant predictor ...
KEY FINDING: A handgrip strength of 102.5 kgf was identified as a cutoff point to achieve a score of 70 on the Spinal Cord Independence Measure (SCIM-III).
Curr Opin Pharmacol, 2021 • October 1, 2021
Severe SCI leads to rapid muscle atrophy due to neural insult, paralysis, systemic inflammation, hormonal imbalances, and glucocorticoid treatment. The review discusses the SCI muscle phenotype, molec...
KEY FINDING: Muscle loss after SCI is more rapid than in other disuse conditions, with distinct molecular signaling cascades.
Journal of Musculoskeletal and Neuronal Interactions, 2021 • April 4, 2021
This study aimed to identify key molecules involved in skeletal muscle atrophy after spinal cord injury (SCI) using bioinformatics analysis of the GSE21497 dataset. The analysis revealed 412 different...
KEY FINDING: UBE2D1, JUN, and FBXO32 are identified as key genes related to skeletal muscle atrophy after SCI, suggesting their potential involvement in the progression of muscle wasting.
The Journal of Spinal Cord Medicine, 2023 • March 1, 2023
The review highlights the potential utility of ALP and B-ALP in assessing changes in bone turnover in humans with SCI, but evidence in animal models is less compelling. The association between ALP and...
KEY FINDING: Evidence regarding changes in ALP levels in individuals with SCI compared to controls is conflicting.
International Journal of Molecular Sciences, 2022 • January 6, 2022
Spinal cord injury (SCI) leads to paralysis and a unique form of neurogenic disuse osteoporosis, heightening fracture risk at the distal femur and proximal tibia. The review identifies factors impacti...
KEY FINDING: Bone loss after SCI is distinct from other disuse conditions in both severity and mechanism.
BMC Musculoskeletal Disorders, 2022 • January 5, 2022
This cross-sectional study examined the relationships between physical activity, smoking status, body composition, muscle strength, and forearm bone mineral density (BMD) in adult men after spinal cor...
KEY FINDING: Active male smokers after SCI had significantly lower BMD dis, BMC dis and prox, T-score dis, and prox than male non-smokers after SCI.
Top Spinal Cord Inj Rehabil, 2022 • January 1, 2022
This retrospective study examined bone health changes in 79 children with AFM and found a high prevalence of low bone mass (78%) among those who had DXA scans. The study highlights the importance of m...
KEY FINDING: A significant percentage (78%) of children with AFM in the study were diagnosed with low bone mass.
Bone Research, 2022 • October 11, 2022
This study investigates the cellular origin of neurogenic heterotopic ossifications (NHOs), which frequently develop in muscles after spinal cord injuries (SCIs). Using lineage-tracing experiments in ...
KEY FINDING: NHOs developing after SCI in injured muscles in mice are not derived from muscle SCs. We also reveal that NHOs only develop in areas of the injured muscle where SCs fail to regenerate myofibers.
Spinal Cord Series and Cases, 2022 • February 20, 2022
This paper introduces a preliminary algorithm designed to mitigate fragility fracture risk during exoskeleton-assisted walking in individuals with chronic spinal cord injury, based on bone mineral den...
KEY FINDING: The developed algorithm classifies individuals into osteoporotic, osteopenic, and preserved bone mineral density profiles, assigning them to corresponding slow, moderate, and fast progression exoskeleton-assisted walking programs.