Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 4,991-5,000 of 5,253 results
Neurosci Bull, 2013 • August 1, 2013
Membrane disruption has serious downstream structural and functional consequences in the mechanical injury of neuronal tissue. PEG-mediated resealing of cell membranes is a practical method to repair ...
KEY FINDING: Polyethylene glycol (PEG) can reseal axonal membranes following various injuries in multiple in vitro and in vivo injury models.
Nat Cell Biol, 2018 • August 1, 2018
This study reveals a previously unappreciated function of FAPs as a source of pro-atrophic and pro-fibrotic signals in denervated muscles, particularly due to the aberrant activation of IL6-STAT3 sign...
KEY FINDING: Denervation leads to the accumulation of FAPs in skeletal muscles, without a corresponding increase in macrophages or muscle stem cells.
PLoS ONE, 2012 • August 13, 2012
This study investigates the potential neuroprotective effects of G-CSF on synaptic elements related to spinal alpha-motoneurons following sciatic nerve axotomy in MDX mice, an animal model for Duchenn...
KEY FINDING: G-CSF treatment led to a greater preservation of synaptic inputs after injury in MDX mice compared with untreated and placebo groups.
The Journal of Neuroscience, 2001 • December 1, 2001
This study investigates axonal regeneration and functional recovery after complete spinal cord transection in adult rats using fetal spinal cord transplants and neurotrophins. The key finding is that ...
KEY FINDING: Delayed treatment with fetal spinal cord transplants and neurotrophins (BDNF or NT-3) significantly increased axonal regeneration from supraspinal pathways after complete spinal cord transection in rats.
Journal of Neuroinflammation, 2024 • November 18, 2024
This study reveals CD22 as a key molecular switch governing the beneficial effects of microglia and Gr-1+ myeloid cells in NMOSD pathology. CD22 blockade exacerbated NMOSD lesions, astrocyte loss, and...
KEY FINDING: CD22 is expressed in B cells, neutrophils, monocytes, and microglia-derived exosomes in human peripheral blood from NMOSD patients and controls, as well as in a mouse model of NMOSD.
Brain Res, 2020 • August 1, 2020
Axonal injury in the PNS invokes axon-to-soma and axon-to-nucleus signals through back-propagating wave of Ca2+ and retrograde transport of signaling proteins that change gene expression to support re...
KEY FINDING: Increased axoplasmic calcium is an early response to initiate regenerative growth programs, but excessive levels can trigger axon degeneration.
Neural Regeneration Research, 2017 • March 1, 2017
The study aimed to determine whether a relationship exists between estrogen and NMDAR1 in peripheral nerve pain using a rat model of chronic sciatic nerve constriction injury. Rats administered estrad...
KEY FINDING: Estrogen administration significantly reduced mechanical and thermal pain thresholds in rats with chronic constriction of the sciatic nerve.
BMC Neurology, 2012 • August 16, 2012
The DiPALS study is a multi-centre randomised controlled trial designed to evaluate the effectiveness of diaphragm pacing (DP) in addition to non-invasive ventilation (NIV) for patients with motor neu...
KEY FINDING: The primary objective of this trial will be to evaluate the effect of Diaphragm Pacing (DP) on survival over the study duration in patients with MND/ amyotrophic lateral sclerosis (ALS) with respiratory muscle weakness.
Neural Regeneration Research, 2014 • July 1, 2014
Myelin regeneration is critical for treating CNS disorders like MS and SCI, as it restores neurophysiology and protects axons from degeneration. Understanding the mechanisms of remyelination is essent...
KEY FINDING: Myelin regeneration shares similarities with myelin development, involving OPC proliferation, migration, differentiation, and myelination, but remyelinated axons often have thinner myelin sheaths and different nodal domain cytoarchitecture.
Scientific Reports, 2021 • May 12, 2021
This study presents the first MRI atlas of the juvenile axolotl brain, comprising 82 and 64 regions of interest, segmented based on embryological origin and hemispheric division. The MRI atlas allows ...
KEY FINDING: The study successfully created an MRI atlas of the axolotl brain, delineating 82 regions of interest (ROIs) and a simplified version with 64 ROIs.