Browse the latest research summaries in the field of neurology for spinal cord injury patients and caregivers.
Showing 5,001-5,010 of 5,253 results
Journal of Neuroinflammation, 2022 • January 1, 2022
This study investigates the role of the PDGFRβ pathway in fibrotic scar formation after spinal cord injury (SCI) and the therapeutic potential of SU16f, a PDGFRβ inhibitor. The results demonstrate tha...
KEY FINDING: PDGFB is mainly secreted by astrocytes, while PDGFD is mainly secreted by macrophages/microglia and fibroblasts after SCI.
Computational Intelligence and Neuroscience, 2018 • August 7, 2018
This review discusses the challenges and potential of automated detection algorithms for high-frequency oscillations (HFOs) in scalp EEG, highlighting their importance as markers for epileptogenicity....
KEY FINDING: HFOs may be a reliable and accurate (spatial) marker that should be taken into account in presurgical evaluation of patients.
BMC Musculoskeletal Disorders, 2018 • December 5, 2018
This study assessed the reliability and reproducibility of diffusion-weighted MRI (DW-MRI) in lower limb muscles, both in healthy individuals and those with motor incomplete spinal cord injury (SCI). ...
KEY FINDING: The intra- and inter-rater reliability of the ADC measurements were high, averaging 0.89 and 0.79, respectively.
Spinal Cord Series and Cases, 2018 • January 1, 2018
The anal exam is an integral part of the International Standards for Neurologic Classification of Spinal Cord Injury (ISNCSCI), but its importance has been debated. Previnaire emphasizes the importanc...
KEY FINDING: The ISNCSCI has undergone repeated modifications to improve accuracy and address difficulties in initial assessments, highlighting the complexity of neurological classification.
Molecular Neurobiology, 2024 • September 6, 2023
The study investigated the role of the transcription factor Ets1 in spinal cord development and regeneration, finding it highly expressed during the embryonic period and decreasing with development. K...
KEY FINDING: Ets1 is highly expressed in the spinal cord during the embryonic period and decreases during development.
Brain, 2016 • March 17, 2016
The study demonstrates that Nrg1 is essential for remyelination of dorsal column axons by PNS-like Schwann cells after spinal cord injury. Data indicate that the centrally remyelinating Schwann cells ...
KEY FINDING: Ablation of Nrg1 prevents Schwann cell-mediated remyelination of dorsal column axons after spinal cord injury.
Frontiers in Neuroscience, 2020 • March 3, 2020
This study investigated the role of platelets in Alzheimer's disease (AD) using APP-PS1 transgenic mice, which exhibit severe amyloid plaque formation. The research focused on the presence, location, ...
KEY FINDING: APP-PS1 mice showed a higher number of platelets in the brain parenchyma compared to WT controls, indicating platelet invasion into the brain.
Frontiers in Neuroscience, 2017 • February 21, 2017
Following damage to the axons of central nervous system (CNS) and peripheral nervous system (PNS) neurons, a number of cellular and molecular processes are initiated to promote regeneration of damaged...
KEY FINDING: HSP27 upregulation and phosphorylation are required for injured sensory and motor neuron survival after sciatic nerve transection.
Laser Therapy, 2017 • May 6, 2017
The study evaluated the effectiveness of combining laser therapy and Grimaldi’s Muscle Shortening Manoeuvre (GMSM) for improving motor control in patients with incomplete spinal cord injuries (SCI). T...
KEY FINDING: Patients receiving laser therapy and GMSM showed significant improvements in surface tactile sensitivity compared to the control group after one and three months.
Brain Res., 2006 • December 13, 2006
This study investigates the integration of transplanted olfactory ensheathing cells (OECs) into peripheral nerve injuries, specifically a sciatic nerve crush lesion in rats. The results show that tran...
KEY FINDING: Transplanted OECs survive in the lesion and distribute along regenerated axons in the peripheral nerve.